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Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice
المؤلفون المشاركون
Wu, Dongdong
Li, Hui
Li, Yanzhang
Gao, Biao
Li, Mengling
Yao, Ling
Wang, Shuaiwei
Chen, Mingliang
Ma, Chunyan
Ji, Ailing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Obesity is prevalent worldwide and is a major risk factor for the development and progression of kidney disease.
Hydrogen sulfide (H2S) plays an important role in renal physiological and pathophysiological processes.
However, whether H2S is able to mitigate kidney injury induced by obesity in mice remains unclear.
In this study, we demonstrated that H2S significantly reduced the accumulation of lipids in the kidneys of high fat diet- (HFD-) induced obese mice.
The results of hematoxylin and eosin, periodic acid-Schiff, and Masson’s trichrome staining showed that H2S ameliorated the kidney structure, decreased the extent of interstitial injury, and reduced the degree of kidney fibrosis in HFD-induced obese mice.
We found that H2S decreased the expression levels of tumor necrosis factor-α, interleukin- (IL-) 6, and monocyte chemoattractant protein-1 but increased the expression level of IL-10.
Furthermore, H2S treatment decreased the protein expression of p50, p65, and p-p65 in the kidney of HFD-induced obese mice.
In conclusion, H2S is able to mitigate renal injury in HFD-induced obese mice through the reduction of kidney inflammation by downregulating the expression of nuclear factor-kappa B.
H2S or its releasing compounds may serve as a potential therapeutic molecule for obesity-induced kidney injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Dongdong& Gao, Biao& Li, Mengling& Yao, Ling& Wang, Shuaiwei& Chen, Mingliang…[et al.]. 2016. Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113734
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Dongdong…[et al.]. Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113734
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Dongdong& Gao, Biao& Li, Mengling& Yao, Ling& Wang, Shuaiwei& Chen, Mingliang…[et al.]. Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113734
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113734
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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