Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice
Joint Authors
Wu, Dongdong
Li, Hui
Li, Yanzhang
Gao, Biao
Li, Mengling
Yao, Ling
Wang, Shuaiwei
Chen, Mingliang
Ma, Chunyan
Ji, Ailing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Obesity is prevalent worldwide and is a major risk factor for the development and progression of kidney disease.
Hydrogen sulfide (H2S) plays an important role in renal physiological and pathophysiological processes.
However, whether H2S is able to mitigate kidney injury induced by obesity in mice remains unclear.
In this study, we demonstrated that H2S significantly reduced the accumulation of lipids in the kidneys of high fat diet- (HFD-) induced obese mice.
The results of hematoxylin and eosin, periodic acid-Schiff, and Masson’s trichrome staining showed that H2S ameliorated the kidney structure, decreased the extent of interstitial injury, and reduced the degree of kidney fibrosis in HFD-induced obese mice.
We found that H2S decreased the expression levels of tumor necrosis factor-α, interleukin- (IL-) 6, and monocyte chemoattractant protein-1 but increased the expression level of IL-10.
Furthermore, H2S treatment decreased the protein expression of p50, p65, and p-p65 in the kidney of HFD-induced obese mice.
In conclusion, H2S is able to mitigate renal injury in HFD-induced obese mice through the reduction of kidney inflammation by downregulating the expression of nuclear factor-kappa B.
H2S or its releasing compounds may serve as a potential therapeutic molecule for obesity-induced kidney injury.
American Psychological Association (APA)
Wu, Dongdong& Gao, Biao& Li, Mengling& Yao, Ling& Wang, Shuaiwei& Chen, Mingliang…[et al.]. 2016. Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113734
Modern Language Association (MLA)
Wu, Dongdong…[et al.]. Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113734
American Medical Association (AMA)
Wu, Dongdong& Gao, Biao& Li, Mengling& Yao, Ling& Wang, Shuaiwei& Chen, Mingliang…[et al.]. Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113734