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Dexamethasone Suppresses Oxysterol-Induced Differentiation of Monocytic Cells
المؤلفون المشاركون
Son, Yonghae
Kim, Bo-Young
Eo, Seong-Kug
Park, Young Chul
Kim, Koanhoi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Oxysterol like 27-hydroxycholesterol (27OHChol) has been reported to induce differentiation of monocytic cells into a mature dendritic cell phenotype.
We examined whether dexamethasone (Dx) affects 27OHChol-induced differentiation using THP-1 cells.
Treatment of monocytic cells with Dx resulted in almost complete inhibition of transcription and surface expression of CD80, CD83, and CD88 induced by 27OHChol.
Elevated surface levels of MHC class I and II molecules induced by 27OHChol were reduced to basal levels by treatment with Dx.
A decreased endocytosis ability caused by 27OHChol was recovered by Dx.
We also examined effects of Dx on expression of CD molecules involved in atherosclerosis.
Increased levels of surface protein and transcription of CD105, CD137, and CD166 by treatment with 27OHChol were significantly inhibited by cotreatment with Dx.
These results indicate that Dx inhibits 27OHChol-induced differentiation of monocytic cells into a mature dendritic cell phenotype and expression of CD molecules whose levels are associated with atherosclerosis.
In addition, we examined phosphorylation of AKT induced by 27OHChol and effect of Dx, where cotreatment with Dx inhibited the phosphorylation of AKT.
The current study reports that Dx regulates oxysterol-mediated dendritic cell differentiation of monocytic cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Son, Yonghae& Kim, Bo-Young& Eo, Seong-Kug& Park, Young Chul& Kim, Koanhoi. 2016. Dexamethasone Suppresses Oxysterol-Induced Differentiation of Monocytic Cells. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113753
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Son, Yonghae…[et al.]. Dexamethasone Suppresses Oxysterol-Induced Differentiation of Monocytic Cells. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113753
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Son, Yonghae& Kim, Bo-Young& Eo, Seong-Kug& Park, Young Chul& Kim, Koanhoi. Dexamethasone Suppresses Oxysterol-Induced Differentiation of Monocytic Cells. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113753
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113753
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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