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Dexamethasone Suppresses Oxysterol-Induced Differentiation of Monocytic Cells
Joint Authors
Son, Yonghae
Kim, Bo-Young
Eo, Seong-Kug
Park, Young Chul
Kim, Koanhoi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oxysterol like 27-hydroxycholesterol (27OHChol) has been reported to induce differentiation of monocytic cells into a mature dendritic cell phenotype.
We examined whether dexamethasone (Dx) affects 27OHChol-induced differentiation using THP-1 cells.
Treatment of monocytic cells with Dx resulted in almost complete inhibition of transcription and surface expression of CD80, CD83, and CD88 induced by 27OHChol.
Elevated surface levels of MHC class I and II molecules induced by 27OHChol were reduced to basal levels by treatment with Dx.
A decreased endocytosis ability caused by 27OHChol was recovered by Dx.
We also examined effects of Dx on expression of CD molecules involved in atherosclerosis.
Increased levels of surface protein and transcription of CD105, CD137, and CD166 by treatment with 27OHChol were significantly inhibited by cotreatment with Dx.
These results indicate that Dx inhibits 27OHChol-induced differentiation of monocytic cells into a mature dendritic cell phenotype and expression of CD molecules whose levels are associated with atherosclerosis.
In addition, we examined phosphorylation of AKT induced by 27OHChol and effect of Dx, where cotreatment with Dx inhibited the phosphorylation of AKT.
The current study reports that Dx regulates oxysterol-mediated dendritic cell differentiation of monocytic cells.
American Psychological Association (APA)
Son, Yonghae& Kim, Bo-Young& Eo, Seong-Kug& Park, Young Chul& Kim, Koanhoi. 2016. Dexamethasone Suppresses Oxysterol-Induced Differentiation of Monocytic Cells. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113753
Modern Language Association (MLA)
Son, Yonghae…[et al.]. Dexamethasone Suppresses Oxysterol-Induced Differentiation of Monocytic Cells. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113753
American Medical Association (AMA)
Son, Yonghae& Kim, Bo-Young& Eo, Seong-Kug& Park, Young Chul& Kim, Koanhoi. Dexamethasone Suppresses Oxysterol-Induced Differentiation of Monocytic Cells. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113753