Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice
المؤلفون المشاركون
Yang, Xiu Hong
Pan, Yu
Zhan, Xiao Li
Zhang, Bao Long
Guo, Li Li
Jin, Hui Min
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-06
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Epigallocatechin-3-gallate (EGCG), extracted from green tea, has been shown to have antioxidative activity.
In the present study, we evaluated the effect of EGCG on the kidney function in db/db mice and also tried to investigate the underlying mechanism of the renoprotective effects of EGCG in both animals and cells.
EGCG treatment could decrease the level of urinary protein, 8-iso-PGF2a, and Ang II.
Moreover, EGCG could also change the level of several parameters associated with oxidative stress.
In addition, the protein expression levels of AT-1R, p22-phox, p47-phox, p-ERK1/2, p-p38 MAPK, TGF-β1, and α-SMA in diabetic db/db mice were upregulated, and all of these symptoms were downregulated with the treatment of EGCG at 50 and 100 mg/kg/d.
Furthermore, the pathological changes were ameliorated in db/db mice after EGCG treatment.
HK-2 cell-based experiments indicated that EGCG could inhibit the expression of MAPK pathways, which is the downstream effector of Ang II mediated oxidative stress.
All these results indicated that EGCG treatment could ameliorate changes of renal pathology and delay the progression of DKD by suppressing hyperglycemia-induced oxidative stress in diabetic db/db mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xiu Hong& Pan, Yu& Zhan, Xiao Li& Zhang, Bao Long& Guo, Li Li& Jin, Hui Min. 2016. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xiu Hong…[et al.]. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xiu Hong& Pan, Yu& Zhan, Xiao Li& Zhang, Bao Long& Guo, Li Li& Jin, Hui Min. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر