Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice

Joint Authors

Yang, Xiu Hong
Pan, Yu
Zhan, Xiao Li
Zhang, Bao Long
Guo, Li Li
Jin, Hui Min

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-09-06

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Biology

Abstract EN

Epigallocatechin-3-gallate (EGCG), extracted from green tea, has been shown to have antioxidative activity.

In the present study, we evaluated the effect of EGCG on the kidney function in db/db mice and also tried to investigate the underlying mechanism of the renoprotective effects of EGCG in both animals and cells.

EGCG treatment could decrease the level of urinary protein, 8-iso-PGF2a, and Ang II.

Moreover, EGCG could also change the level of several parameters associated with oxidative stress.

In addition, the protein expression levels of AT-1R, p22-phox, p47-phox, p-ERK1/2, p-p38 MAPK, TGF-β1, and α-SMA in diabetic db/db mice were upregulated, and all of these symptoms were downregulated with the treatment of EGCG at 50 and 100 mg/kg/d.

Furthermore, the pathological changes were ameliorated in db/db mice after EGCG treatment.

HK-2 cell-based experiments indicated that EGCG could inhibit the expression of MAPK pathways, which is the downstream effector of Ang II mediated oxidative stress.

All these results indicated that EGCG treatment could ameliorate changes of renal pathology and delay the progression of DKD by suppressing hyperglycemia-induced oxidative stress in diabetic db/db mice.

American Psychological Association (APA)

Yang, Xiu Hong& Pan, Yu& Zhan, Xiao Li& Zhang, Bao Long& Guo, Li Li& Jin, Hui Min. 2016. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113759

Modern Language Association (MLA)

Yang, Xiu Hong…[et al.]. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113759

American Medical Association (AMA)

Yang, Xiu Hong& Pan, Yu& Zhan, Xiao Li& Zhang, Bao Long& Guo, Li Li& Jin, Hui Min. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113759

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1113759