Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice
Joint Authors
Yang, Xiu Hong
Pan, Yu
Zhan, Xiao Li
Zhang, Bao Long
Guo, Li Li
Jin, Hui Min
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Epigallocatechin-3-gallate (EGCG), extracted from green tea, has been shown to have antioxidative activity.
In the present study, we evaluated the effect of EGCG on the kidney function in db/db mice and also tried to investigate the underlying mechanism of the renoprotective effects of EGCG in both animals and cells.
EGCG treatment could decrease the level of urinary protein, 8-iso-PGF2a, and Ang II.
Moreover, EGCG could also change the level of several parameters associated with oxidative stress.
In addition, the protein expression levels of AT-1R, p22-phox, p47-phox, p-ERK1/2, p-p38 MAPK, TGF-β1, and α-SMA in diabetic db/db mice were upregulated, and all of these symptoms were downregulated with the treatment of EGCG at 50 and 100 mg/kg/d.
Furthermore, the pathological changes were ameliorated in db/db mice after EGCG treatment.
HK-2 cell-based experiments indicated that EGCG could inhibit the expression of MAPK pathways, which is the downstream effector of Ang II mediated oxidative stress.
All these results indicated that EGCG treatment could ameliorate changes of renal pathology and delay the progression of DKD by suppressing hyperglycemia-induced oxidative stress in diabetic db/db mice.
American Psychological Association (APA)
Yang, Xiu Hong& Pan, Yu& Zhan, Xiao Li& Zhang, Bao Long& Guo, Li Li& Jin, Hui Min. 2016. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113759
Modern Language Association (MLA)
Yang, Xiu Hong…[et al.]. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113759
American Medical Association (AMA)
Yang, Xiu Hong& Pan, Yu& Zhan, Xiao Li& Zhang, Bao Long& Guo, Li Li& Jin, Hui Min. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic dbdb Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113759