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Renalase as a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury
المؤلفون المشاركون
Li, Huili
Huang, Kun
Wang, Jiliang
Guo, Jianrong
Liu, Hongli
Niu, Yanfeng
Wang, Lixia
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Hepatic ischemia-reperfusion (I/R) injury is a serious complication in clinical practice.
However, no efficient biomarkers are available for the evaluation of the severity of I/R injury.
Recently, renalase has been reported to be implicated in the I/R injury of various organs.
This protein is secreted into the blood in response to increased oxidative stress.
To investigate the responsiveness of renalase to oxidative stress, we examined the changes of renalase in cell and mouse models.
We observed a significant increase of renalase expression in HepG2 cells in a time- and dose-dependent manner when treated with H2O2.
Renalase expression also increased significantly in liver tissues that underwent the hepatic I/R process.
The increased renalase levels could be efficiently suppressed by antioxidants in vitro and in vivo.
Furthermore, serum renalase levels were significantly increased in the mouse models and also efficiently suppressed by antioxidants treatment.
The variation trends are consistent between renalase and liver enzymes in the mouse models.
In conclusion, renalase is highly sensitive and responsive to oxidative stress in vitro and in vivo.
Moreover, renalase can be detected in the blood.
These properties make renalase a highly promising biomarker for the evaluation of the severity of hepatic I/R injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Huili& Guo, Jianrong& Liu, Hongli& Niu, Yanfeng& Wang, Lixia& Huang, Kun…[et al.]. 2016. Renalase as a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113780
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Huili…[et al.]. Renalase as a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113780
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Huili& Guo, Jianrong& Liu, Hongli& Niu, Yanfeng& Wang, Lixia& Huang, Kun…[et al.]. Renalase as a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113780
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113780
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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