Renalase as a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury
Joint Authors
Li, Huili
Huang, Kun
Wang, Jiliang
Guo, Jianrong
Liu, Hongli
Niu, Yanfeng
Wang, Lixia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hepatic ischemia-reperfusion (I/R) injury is a serious complication in clinical practice.
However, no efficient biomarkers are available for the evaluation of the severity of I/R injury.
Recently, renalase has been reported to be implicated in the I/R injury of various organs.
This protein is secreted into the blood in response to increased oxidative stress.
To investigate the responsiveness of renalase to oxidative stress, we examined the changes of renalase in cell and mouse models.
We observed a significant increase of renalase expression in HepG2 cells in a time- and dose-dependent manner when treated with H2O2.
Renalase expression also increased significantly in liver tissues that underwent the hepatic I/R process.
The increased renalase levels could be efficiently suppressed by antioxidants in vitro and in vivo.
Furthermore, serum renalase levels were significantly increased in the mouse models and also efficiently suppressed by antioxidants treatment.
The variation trends are consistent between renalase and liver enzymes in the mouse models.
In conclusion, renalase is highly sensitive and responsive to oxidative stress in vitro and in vivo.
Moreover, renalase can be detected in the blood.
These properties make renalase a highly promising biomarker for the evaluation of the severity of hepatic I/R injury.
American Psychological Association (APA)
Li, Huili& Guo, Jianrong& Liu, Hongli& Niu, Yanfeng& Wang, Lixia& Huang, Kun…[et al.]. 2016. Renalase as a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113780
Modern Language Association (MLA)
Li, Huili…[et al.]. Renalase as a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113780
American Medical Association (AMA)
Li, Huili& Guo, Jianrong& Liu, Hongli& Niu, Yanfeng& Wang, Lixia& Huang, Kun…[et al.]. Renalase as a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113780