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Spironolactone Effect in Hepatic IschemiaReperfusion Injury in Wistar Rats
المؤلفون المشاركون
Camara-Lemarroy, Carlos Rodrigo
Cordero-Pérez, Paula
Alarcón-Galván, Gabriela
Muñoz-Espinosa, Linda E.
Jiménez Pérez, Julio César
Torres González, Liliana
Perales Quintana, Marlene Marisol
Zapata Chavira, Homero
Guzmán de la Garza, Francisco Javier
Fernández Garza, Nancy Esthela
Pérez Rodríguez, Edelmiro
Casillas-Ramírez, A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
Ischemia/reperfusion (IR) injury, often associated with liver surgery, is an unresolved problem in the clinical practice.
Spironolactone is an antagonist of aldosterone that has shown benefits over IR injury in several tissues, but its effects in hepatic IR are unknown.
Objective.
To evaluate the effect of spironolactone on IR-induced damage in liver.
Materials and Methods.
Total hepatic ischemia was induced in rats for 20 min followed by 60 min of reperfusion.
Spironolactone was administered and hepatic injury, cytokine production, and oxidative stress were assessed.
Results.
After IR, increased transaminases levels and widespread acute inflammatory infiltrate, disorganization of hepatic hemorrhage trabeculae, and presence of apoptotic bodies were observed.
Administration of SPI reduced biochemical and histological parameters of liver injury.
SPI treatment increased IL-6 levels when compared with IR group but did not modify either IL-1β or TNF-α with respect to IR group.
Regarding oxidative stress, increased levels of catalase activity were recorded in IR + SPI group in comparison with group without treatment, whereas MDA levels were similar in IR + SPI and IR groups.
Conclusions.
Spironolactone reduced the liver damage induced by IR, and this was associated with an increase in IL-6 production and catalase activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiménez Pérez, Julio César& Casillas-Ramírez, A.& Torres González, Liliana& Muñoz-Espinosa, Linda E.& Perales Quintana, Marlene Marisol& Alarcón-Galván, Gabriela…[et al.]. 2015. Spironolactone Effect in Hepatic IschemiaReperfusion Injury in Wistar Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113787
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiménez Pérez, Julio César…[et al.]. Spironolactone Effect in Hepatic IschemiaReperfusion Injury in Wistar Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113787
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiménez Pérez, Julio César& Casillas-Ramírez, A.& Torres González, Liliana& Muñoz-Espinosa, Linda E.& Perales Quintana, Marlene Marisol& Alarcón-Galván, Gabriela…[et al.]. Spironolactone Effect in Hepatic IschemiaReperfusion Injury in Wistar Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113787
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113787
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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