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Spironolactone Effect in Hepatic IschemiaReperfusion Injury in Wistar Rats
Joint Authors
Camara-Lemarroy, Carlos Rodrigo
Cordero-Pérez, Paula
Alarcón-Galván, Gabriela
Muñoz-Espinosa, Linda E.
Jiménez Pérez, Julio César
Torres González, Liliana
Perales Quintana, Marlene Marisol
Zapata Chavira, Homero
Guzmán de la Garza, Francisco Javier
Fernández Garza, Nancy Esthela
Pérez Rodríguez, Edelmiro
Casillas-Ramírez, A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Ischemia/reperfusion (IR) injury, often associated with liver surgery, is an unresolved problem in the clinical practice.
Spironolactone is an antagonist of aldosterone that has shown benefits over IR injury in several tissues, but its effects in hepatic IR are unknown.
Objective.
To evaluate the effect of spironolactone on IR-induced damage in liver.
Materials and Methods.
Total hepatic ischemia was induced in rats for 20 min followed by 60 min of reperfusion.
Spironolactone was administered and hepatic injury, cytokine production, and oxidative stress were assessed.
Results.
After IR, increased transaminases levels and widespread acute inflammatory infiltrate, disorganization of hepatic hemorrhage trabeculae, and presence of apoptotic bodies were observed.
Administration of SPI reduced biochemical and histological parameters of liver injury.
SPI treatment increased IL-6 levels when compared with IR group but did not modify either IL-1β or TNF-α with respect to IR group.
Regarding oxidative stress, increased levels of catalase activity were recorded in IR + SPI group in comparison with group without treatment, whereas MDA levels were similar in IR + SPI and IR groups.
Conclusions.
Spironolactone reduced the liver damage induced by IR, and this was associated with an increase in IL-6 production and catalase activity.
American Psychological Association (APA)
Jiménez Pérez, Julio César& Casillas-Ramírez, A.& Torres González, Liliana& Muñoz-Espinosa, Linda E.& Perales Quintana, Marlene Marisol& Alarcón-Galván, Gabriela…[et al.]. 2015. Spironolactone Effect in Hepatic IschemiaReperfusion Injury in Wistar Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113787
Modern Language Association (MLA)
Jiménez Pérez, Julio César…[et al.]. Spironolactone Effect in Hepatic IschemiaReperfusion Injury in Wistar Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113787
American Medical Association (AMA)
Jiménez Pérez, Julio César& Casillas-Ramírez, A.& Torres González, Liliana& Muñoz-Espinosa, Linda E.& Perales Quintana, Marlene Marisol& Alarcón-Galván, Gabriela…[et al.]. Spironolactone Effect in Hepatic IschemiaReperfusion Injury in Wistar Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113787