Protection of Pentoxifylline against Testis Injury Induced by Intermittent Hypobaric Hypoxia
المؤلفون المشاركون
Yao, Chen
Li, Gang
Qian, Yeyong
Cai, Ming
Yin, Hong
Xiao, Li
Tang, Wei
Guo, Fengjie
Shi, Bingyi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
To investigate the effect of pentoxifylline (PTX) on spermatogenesis dysfunction induced by intermittent hypobaric hypoxia (IHH) and unveil the underlying mechanism, experimental animals were assigned to Control, IHH+Vehicle, and IHH+PTX groups and exposed to 4 cycles of 96 h of hypobaric hypoxia followed by 96 h of normobaric normoxia for 32 days.
PTX was administered for 32 days.
Blood and tissue samples were collected 7 days thereafter.
Serum malondialdehyde levels were used to assess lipid peroxidation; ferric-reducing antioxidant power (FRAP), superoxide dismutase, and catalase and glutathione peroxidase enzyme activities were assessed to determine antioxidant capacity in various samples.
Testis histopathology was assessed after hematoxylin-eosin staining by Johnsen’s testicular scoring system.
Meanwhile, testosterone synthase and vimentin amounts were assessed by immunohistochemistry.
Sperm count, motility, and density were assessed to determine epididymal sperm quality.
IHH treatment induced significant pathological changes in testicular tissue and enhanced serum lipid peroxide levels, while reducing serum FRAP, antioxidant enzyme activities, and testosterone synthase expression.
Moreover, IHH impaired epididymal sperm quality and vimentin structure in Sertoli cells.
Oral administration of PTX improved the pathological changes in the testis.
IHH may impair spermatogenesis function of testicular tissues by inducing oxidative stress, but this impairment could be attenuated by administration of PTX.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Chen& Li, Gang& Qian, Yeyong& Cai, Ming& Yin, Hong& Xiao, Li…[et al.]. 2016. Protection of Pentoxifylline against Testis Injury Induced by Intermittent Hypobaric Hypoxia. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Chen…[et al.]. Protection of Pentoxifylline against Testis Injury Induced by Intermittent Hypobaric Hypoxia. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Chen& Li, Gang& Qian, Yeyong& Cai, Ming& Yin, Hong& Xiao, Li…[et al.]. Protection of Pentoxifylline against Testis Injury Induced by Intermittent Hypobaric Hypoxia. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر