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Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat
المؤلفون المشاركون
Li, Jian-Dong
Cheng, Ai-Yuan
Huo, Yan-Li
Fan, Jie
Zhang, Yu-Ping
Fang, Zhi-Qin
Sun, Hong-Sheng
Peng, Wei
Zhang, Jin-Shun
Wang, Hai-Ping
Xue, Bao-Jian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Heart failure (HF) is characterized by cardiac dysfunction along with autonomic unbalance that is associated with increased renin-angiotensin system (RAS) activity and elevated levels of proinflammatory cytokines (PICs).
Renal denervation (RD) has been shown to improve cardiac function in HF, but the protective mechanisms remain unclear.
The present study tested the hypothesis that RD ameliorates isoproterenol- (ISO-) induced HF through regulation of brain RAS and PICs.
Chronic ISO infusion resulted in remarked decrease in blood pressure (BP) and increase in heart rate and cardiac dysfunction, which was accompanied by increased BP variability and decreased baroreflex sensitivity and HR variability.
Most of these adverse effects of ISO on cardiac and autonomic function were reversed by RD.
Furthermore, ISO upregulated mRNA and protein expressions of several components of the RAS and PICs in the lamina terminalis and hypothalamic paraventricular nucleus, two forebrain nuclei involved in cardiovascular regulations.
RD significantly inhibited the upregulation of these genes.
Either intracerebroventricular AT1-R antagonist, irbesartan, or TNF-α inhibitor, etanercept, mimicked the beneficial actions of RD in the ISO-induced HF.
The results suggest that the RD restores autonomic balance and ameliorates ISO-induced HF and that the downregulated RAS and PICs in the brain contribute to these beneficial effects of RD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jian-Dong& Cheng, Ai-Yuan& Huo, Yan-Li& Fan, Jie& Zhang, Yu-Ping& Fang, Zhi-Qin…[et al.]. 2016. Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113831
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jian-Dong…[et al.]. Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113831
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jian-Dong& Cheng, Ai-Yuan& Huo, Yan-Li& Fan, Jie& Zhang, Yu-Ping& Fang, Zhi-Qin…[et al.]. Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113831
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113831
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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