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Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat
Joint Authors
Li, Jian-Dong
Cheng, Ai-Yuan
Huo, Yan-Li
Fan, Jie
Zhang, Yu-Ping
Fang, Zhi-Qin
Sun, Hong-Sheng
Peng, Wei
Zhang, Jin-Shun
Wang, Hai-Ping
Xue, Bao-Jian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Heart failure (HF) is characterized by cardiac dysfunction along with autonomic unbalance that is associated with increased renin-angiotensin system (RAS) activity and elevated levels of proinflammatory cytokines (PICs).
Renal denervation (RD) has been shown to improve cardiac function in HF, but the protective mechanisms remain unclear.
The present study tested the hypothesis that RD ameliorates isoproterenol- (ISO-) induced HF through regulation of brain RAS and PICs.
Chronic ISO infusion resulted in remarked decrease in blood pressure (BP) and increase in heart rate and cardiac dysfunction, which was accompanied by increased BP variability and decreased baroreflex sensitivity and HR variability.
Most of these adverse effects of ISO on cardiac and autonomic function were reversed by RD.
Furthermore, ISO upregulated mRNA and protein expressions of several components of the RAS and PICs in the lamina terminalis and hypothalamic paraventricular nucleus, two forebrain nuclei involved in cardiovascular regulations.
RD significantly inhibited the upregulation of these genes.
Either intracerebroventricular AT1-R antagonist, irbesartan, or TNF-α inhibitor, etanercept, mimicked the beneficial actions of RD in the ISO-induced HF.
The results suggest that the RD restores autonomic balance and ameliorates ISO-induced HF and that the downregulated RAS and PICs in the brain contribute to these beneficial effects of RD.
American Psychological Association (APA)
Li, Jian-Dong& Cheng, Ai-Yuan& Huo, Yan-Li& Fan, Jie& Zhang, Yu-Ping& Fang, Zhi-Qin…[et al.]. 2016. Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113831
Modern Language Association (MLA)
Li, Jian-Dong…[et al.]. Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113831
American Medical Association (AMA)
Li, Jian-Dong& Cheng, Ai-Yuan& Huo, Yan-Li& Fan, Jie& Zhang, Yu-Ping& Fang, Zhi-Qin…[et al.]. Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113831