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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
المؤلفون المشاركون
Mitic, Tijana
Caporali, Andrea
Lauriola, Angela
D’Arca, Domenico
Davalli, Pierpaola
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-10
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
The aging process worsens the human body functions at multiple levels, thus causing its gradual decrease to resist stress, damage, and disease.
Besides changes in gene expression and metabolic control, the aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS) and/or Reactive Nitrosative Species (RNS).
Specific increases of ROS level have been demonstrated as potentially critical for induction and maintenance of cell senescence process.
Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely.
Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment.
Therapeutic interventions towards senescent cells might allow restoring the health and curing the diseases that share basal processes, rather than curing each disease in separate and symptomatic way.
Here, we review observations on ROS ability of inducing cell senescence through novel mechanisms that underpin aging processes.
Particular emphasis is addressed to the novel mechanisms of ROS involvement in epigenetic regulation of cell senescence and aging, with the aim to individuate specific pathways, which might promote healthy lifespan and improve aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Davalli, Pierpaola& Mitic, Tijana& Caporali, Andrea& Lauriola, Angela& D’Arca, Domenico. 2016. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113832
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Davalli, Pierpaola…[et al.]. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1113832
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Davalli, Pierpaola& Mitic, Tijana& Caporali, Andrea& Lauriola, Angela& D’Arca, Domenico. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113832
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113832
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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