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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
Joint Authors
Mitic, Tijana
Caporali, Andrea
Lauriola, Angela
D’Arca, Domenico
Davalli, Pierpaola
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-10
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The aging process worsens the human body functions at multiple levels, thus causing its gradual decrease to resist stress, damage, and disease.
Besides changes in gene expression and metabolic control, the aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS) and/or Reactive Nitrosative Species (RNS).
Specific increases of ROS level have been demonstrated as potentially critical for induction and maintenance of cell senescence process.
Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely.
Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment.
Therapeutic interventions towards senescent cells might allow restoring the health and curing the diseases that share basal processes, rather than curing each disease in separate and symptomatic way.
Here, we review observations on ROS ability of inducing cell senescence through novel mechanisms that underpin aging processes.
Particular emphasis is addressed to the novel mechanisms of ROS involvement in epigenetic regulation of cell senescence and aging, with the aim to individuate specific pathways, which might promote healthy lifespan and improve aging.
American Psychological Association (APA)
Davalli, Pierpaola& Mitic, Tijana& Caporali, Andrea& Lauriola, Angela& D’Arca, Domenico. 2016. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113832
Modern Language Association (MLA)
Davalli, Pierpaola…[et al.]. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1113832
American Medical Association (AMA)
Davalli, Pierpaola& Mitic, Tijana& Caporali, Andrea& Lauriola, Angela& D’Arca, Domenico. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113832