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Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats
المؤلفون المشاركون
Abbas, Aymn T.
El-Shitany, Nagla A.
Ali, Soad S.
Abdel-dayem, Umama A.
Almasaudi, Saad B.
Al Jaouni, Soad K.
Harakeh, Steve
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Gastric ulcers are among the most common diseases affecting humans.
This study aimed at investigating the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats.
The mechanism by which honey exerts its antiulcer potential was elucidated.
Four groups of rats were used: control, ethanol (ulcer), omeprazole, and manuka honey.
Stomachs were examined macroscopically for hemorrhagic lesions in the glandular mucosa, histopathological changes, and glycoprotein detection.
The effects of oxidative stress were investigated using the following indicators: gastric mucosal nitric oxide (NO), reduced glutathione (GSH), lipid peroxide (MDA, measured as malondialdehyde) glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase.
Plasma tumour necrosis factor-α, interleukin-1β, and IL-6 were also measured.
Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.
It significantly increased gastric mucosal levels of NO, GSH, GPx, and SOD.
Manuka honey also decreased gastric mucosal MDA and plasma TNF-α, IL-1β, and IL-6 concentrations.
In conclusion, manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Almasaudi, Saad B.& El-Shitany, Nagla A.& Abbas, Aymn T.& Abdel-dayem, Umama A.& Ali, Soad S.& Al Jaouni, Soad K.…[et al.]. 2015. Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113847
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Almasaudi, Saad B.…[et al.]. Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113847
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Almasaudi, Saad B.& El-Shitany, Nagla A.& Abbas, Aymn T.& Abdel-dayem, Umama A.& Ali, Soad S.& Al Jaouni, Soad K.…[et al.]. Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113847
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113847
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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