Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats
Joint Authors
Abbas, Aymn T.
El-Shitany, Nagla A.
Ali, Soad S.
Abdel-dayem, Umama A.
Almasaudi, Saad B.
Al Jaouni, Soad K.
Harakeh, Steve
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Gastric ulcers are among the most common diseases affecting humans.
This study aimed at investigating the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats.
The mechanism by which honey exerts its antiulcer potential was elucidated.
Four groups of rats were used: control, ethanol (ulcer), omeprazole, and manuka honey.
Stomachs were examined macroscopically for hemorrhagic lesions in the glandular mucosa, histopathological changes, and glycoprotein detection.
The effects of oxidative stress were investigated using the following indicators: gastric mucosal nitric oxide (NO), reduced glutathione (GSH), lipid peroxide (MDA, measured as malondialdehyde) glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase.
Plasma tumour necrosis factor-α, interleukin-1β, and IL-6 were also measured.
Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.
It significantly increased gastric mucosal levels of NO, GSH, GPx, and SOD.
Manuka honey also decreased gastric mucosal MDA and plasma TNF-α, IL-1β, and IL-6 concentrations.
In conclusion, manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels.
American Psychological Association (APA)
Almasaudi, Saad B.& El-Shitany, Nagla A.& Abbas, Aymn T.& Abdel-dayem, Umama A.& Ali, Soad S.& Al Jaouni, Soad K.…[et al.]. 2015. Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113847
Modern Language Association (MLA)
Almasaudi, Saad B.…[et al.]. Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113847
American Medical Association (AMA)
Almasaudi, Saad B.& El-Shitany, Nagla A.& Abbas, Aymn T.& Abdel-dayem, Umama A.& Ali, Soad S.& Al Jaouni, Soad K.…[et al.]. Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113847