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Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease
المؤلفون المشاركون
García-Arroyo, Fernando Enrique
Loredo-Mendoza, María Lilia
Sánchez-Lozada, Laura Gabriela
Arellano-Mendoza, Monica
García-Trejo, Ehécatl M. A.
Castillo-Hernández, María C.
Guevara-Balcázar, Gustavo
Argüello-García, Raúl
Tapia, Edilia
Arellano, Abraham
Osorio, Horacio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-21
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
This work was performed to study the effect of allicin on hypertension and cardiac function in a rat model of CKD.
The groups were control, CKD (5/6 nephrectomy), and CKD-allicin treated (CKDA) (40 mg/kg day/p.o.).
Blood pressure was monitored (weekly/6 weeks).
The cardiac function, vascular response to angiotensin II, oxidative stress, and heart morphometric parameters were determined.
The CKD group showed hypertension and proteinuria.
The coronary perfusion and left ventricular pressures were decreased in CKD group.
In contrast, the vascular response to angiotensin II and expression of angiotensin II type 1 receptor (AT1R) were increased.
These data were associated with the increment in morphometric parameters (weight of heart and left ventricle, heart/BW and left ventricular mass index, and wall thickness).
Concurrently, the oxidative stress was increased and correlated inversely with the expression of Nrf2, Keap1, and antioxidant enzymes Nrf2-regulated.
Allicin treatment attenuated hypertension and improved the renal and the cardiac dysfunctions; furthermore, it decreased the vascular reactivity to angiotensin II, AT1R overexpression, and preserved morphometric parameters.
Allicin also downregulated Keap1 and increased Nrf2 expression, upregulated the antioxidant enzymes, and reduced oxidative stress.
In conclusion, allicin showed an antihypertensive, nephroprotective, cardioprotective, and antioxidant effects, likely through downregulation of AT1R and Keap1 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
García-Trejo, Ehécatl M. A.& Arellano, Abraham& Argüello-García, Raúl& Loredo-Mendoza, María Lilia& García-Arroyo, Fernando Enrique& Arellano-Mendoza, Monica…[et al.]. 2016. Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113858
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
García-Trejo, Ehécatl M. A.…[et al.]. Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113858
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
García-Trejo, Ehécatl M. A.& Arellano, Abraham& Argüello-García, Raúl& Loredo-Mendoza, María Lilia& García-Arroyo, Fernando Enrique& Arellano-Mendoza, Monica…[et al.]. Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113858
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113858
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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