Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease
Joint Authors
García-Arroyo, Fernando Enrique
Loredo-Mendoza, María Lilia
Sánchez-Lozada, Laura Gabriela
Arellano-Mendoza, Monica
García-Trejo, Ehécatl M. A.
Castillo-Hernández, María C.
Guevara-Balcázar, Gustavo
Argüello-García, Raúl
Tapia, Edilia
Arellano, Abraham
Osorio, Horacio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This work was performed to study the effect of allicin on hypertension and cardiac function in a rat model of CKD.
The groups were control, CKD (5/6 nephrectomy), and CKD-allicin treated (CKDA) (40 mg/kg day/p.o.).
Blood pressure was monitored (weekly/6 weeks).
The cardiac function, vascular response to angiotensin II, oxidative stress, and heart morphometric parameters were determined.
The CKD group showed hypertension and proteinuria.
The coronary perfusion and left ventricular pressures were decreased in CKD group.
In contrast, the vascular response to angiotensin II and expression of angiotensin II type 1 receptor (AT1R) were increased.
These data were associated with the increment in morphometric parameters (weight of heart and left ventricle, heart/BW and left ventricular mass index, and wall thickness).
Concurrently, the oxidative stress was increased and correlated inversely with the expression of Nrf2, Keap1, and antioxidant enzymes Nrf2-regulated.
Allicin treatment attenuated hypertension and improved the renal and the cardiac dysfunctions; furthermore, it decreased the vascular reactivity to angiotensin II, AT1R overexpression, and preserved morphometric parameters.
Allicin also downregulated Keap1 and increased Nrf2 expression, upregulated the antioxidant enzymes, and reduced oxidative stress.
In conclusion, allicin showed an antihypertensive, nephroprotective, cardioprotective, and antioxidant effects, likely through downregulation of AT1R and Keap1 expression.
American Psychological Association (APA)
García-Trejo, Ehécatl M. A.& Arellano, Abraham& Argüello-García, Raúl& Loredo-Mendoza, María Lilia& García-Arroyo, Fernando Enrique& Arellano-Mendoza, Monica…[et al.]. 2016. Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113858
Modern Language Association (MLA)
García-Trejo, Ehécatl M. A.…[et al.]. Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113858
American Medical Association (AMA)
García-Trejo, Ehécatl M. A.& Arellano, Abraham& Argüello-García, Raúl& Loredo-Mendoza, María Lilia& García-Arroyo, Fernando Enrique& Arellano-Mendoza, Monica…[et al.]. Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113858