Hyperglycemia Aggravates Hepatic Ischemia Reperfusion Injury by Inducing Chronic Oxidative Stress and Inflammation
المؤلفون المشاركون
Yao, Weifeng
Chi, Xinjin
Zhang, Yihan
Yuan, Dongdong
Zhu, Qianqian
Liu, Yue
Huang, Fei
Feng, Jiayu
Chen, Xi
Huang, Yong
Hei, Ziqing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-31
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Aim.
To investigate whether hyperglycemia will aggravate hepatic ischemia reperfusion injury (HIRI) and the underlying mechanisms.
Methods.
Control and streptozotocin-induced diabetic Sprague-Dawley rats were subjected to partial hepatic ischemia reperfusion.
Liver histology, transferase, inflammatory cytokines, and oxidative stress were assessed accordingly.
Similarly, BRL-3A hepatocytes were subjected to hypoxia/reoxygenation (H/R) after high (25 mM) or low (5.5 mM) glucose culture.
Cell viability, reactive oxygen species (ROS), and activation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-κB) were determined.
Results.
Compared with control, diabetic rats presented more severe hepatic injury and increased hepatic inflammatory cytokines and oxidative stress.
HIRI in diabetic rats could be ameliorated by pretreatment of N-acetyl-L-cysteine (NAC) or apocynin.
Excessive ROS generation and consequent Nrf2 and NF-κB translocation were determined after high glucose exposure.
NF-κB translocation and its downstream cytokines were further increased in high glucose cultured group after H/R.
While proper regulation of Nrf2 to its downstream antioxidases was observed in low glucose cultured group, no further induction of Nrf2 pathway by H/R after high glucose culture was identified.
Conclusion.
Hyperglycemia aggravates HIRI, which might be attributed to chronic oxidative stress and inflammation and potential malfunction of antioxidative system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yihan& Yuan, Dongdong& Yao, Weifeng& Zhu, Qianqian& Liu, Yue& Huang, Fei…[et al.]. 2016. Hyperglycemia Aggravates Hepatic Ischemia Reperfusion Injury by Inducing Chronic Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113870
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yihan…[et al.]. Hyperglycemia Aggravates Hepatic Ischemia Reperfusion Injury by Inducing Chronic Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113870
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yihan& Yuan, Dongdong& Yao, Weifeng& Zhu, Qianqian& Liu, Yue& Huang, Fei…[et al.]. Hyperglycemia Aggravates Hepatic Ischemia Reperfusion Injury by Inducing Chronic Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113870
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113870
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر