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Colonic and Hepatic Modulation by Lipoic Acid andor N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats
المؤلفون المشاركون
Rabelo, Luíza A.
Nunes-Souza, Valéria
Santos, Juliana Célia F.
de Araújo, Orlando R. P.
de Andrade, Kívia Queiroz
Moura, Fabiana Andréa
Goulart, Marília Oliveira F.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-13
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Lipoic acid (LA) and N-acetylcysteine (NAC) are antioxidant and anti-inflammatory agents that have not yet been tested on mild ulcerative colitis (UC).
This study aims to evaluate the action of LA and/or NAC, on oxidative stress and inflammation markers in colonic and hepatic rat tissues with mild UC, induced by dextran sodium sulfate (DSS) (2% w/v).
LA and/or NAC (100 mg·kg·day−1, each) were given, once a day, in the diet, in a pretreatment phase (7 days) and during UC induction (5 days).
Colitis induction was confirmed by histological and biochemical analyses (high performance liquid chromatography, spectrophotometry, and Multiplex®).
A redox imbalance occurred before an immunological disruption in the colon.
NAC led to a decrease in hydrogen peroxide (H2O2), malondialdehyde (MDA) levels, and myeloperoxidase activity.
In the liver, DSS did not cause damage but treatments with both antioxidants were potentially harmful, with LA increasing MDA and LA + NAC increasing H2O2, tumor necrosis factor alpha, interferon gamma, and transaminases.
In summary, NAC exhibited the highest colonic antioxidant and anti-inflammatory activity, while LA + NAC caused hepatic damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moura, Fabiana Andréa& de Andrade, Kívia Queiroz& de Araújo, Orlando R. P.& Nunes-Souza, Valéria& Santos, Juliana Célia F.& Rabelo, Luíza A.…[et al.]. 2016. Colonic and Hepatic Modulation by Lipoic Acid andor N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113898
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moura, Fabiana Andréa…[et al.]. Colonic and Hepatic Modulation by Lipoic Acid andor N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1113898
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moura, Fabiana Andréa& de Andrade, Kívia Queiroz& de Araújo, Orlando R. P.& Nunes-Souza, Valéria& Santos, Juliana Célia F.& Rabelo, Luíza A.…[et al.]. Colonic and Hepatic Modulation by Lipoic Acid andor N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113898
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113898
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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