Colonic and Hepatic Modulation by Lipoic Acid andor N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats
Joint Authors
Rabelo, Luíza A.
Nunes-Souza, Valéria
Santos, Juliana Célia F.
de Araújo, Orlando R. P.
de Andrade, Kívia Queiroz
Moura, Fabiana Andréa
Goulart, Marília Oliveira F.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-13
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Lipoic acid (LA) and N-acetylcysteine (NAC) are antioxidant and anti-inflammatory agents that have not yet been tested on mild ulcerative colitis (UC).
This study aims to evaluate the action of LA and/or NAC, on oxidative stress and inflammation markers in colonic and hepatic rat tissues with mild UC, induced by dextran sodium sulfate (DSS) (2% w/v).
LA and/or NAC (100 mg·kg·day−1, each) were given, once a day, in the diet, in a pretreatment phase (7 days) and during UC induction (5 days).
Colitis induction was confirmed by histological and biochemical analyses (high performance liquid chromatography, spectrophotometry, and Multiplex®).
A redox imbalance occurred before an immunological disruption in the colon.
NAC led to a decrease in hydrogen peroxide (H2O2), malondialdehyde (MDA) levels, and myeloperoxidase activity.
In the liver, DSS did not cause damage but treatments with both antioxidants were potentially harmful, with LA increasing MDA and LA + NAC increasing H2O2, tumor necrosis factor alpha, interferon gamma, and transaminases.
In summary, NAC exhibited the highest colonic antioxidant and anti-inflammatory activity, while LA + NAC caused hepatic damage.
American Psychological Association (APA)
Moura, Fabiana Andréa& de Andrade, Kívia Queiroz& de Araújo, Orlando R. P.& Nunes-Souza, Valéria& Santos, Juliana Célia F.& Rabelo, Luíza A.…[et al.]. 2016. Colonic and Hepatic Modulation by Lipoic Acid andor N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113898
Modern Language Association (MLA)
Moura, Fabiana Andréa…[et al.]. Colonic and Hepatic Modulation by Lipoic Acid andor N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1113898
American Medical Association (AMA)
Moura, Fabiana Andréa& de Andrade, Kívia Queiroz& de Araújo, Orlando R. P.& Nunes-Souza, Valéria& Santos, Juliana Célia F.& Rabelo, Luíza A.…[et al.]. Colonic and Hepatic Modulation by Lipoic Acid andor N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113898