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Phenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats
المؤلفون المشاركون
Imam, Mustapha Umar
Ismail, Maznah
Ooi, Der-Jiun
Sarega, Nadarajan
Norhaizan, Mohd Esa
Chan, Kim Wei
Zawawi, Norhasnida
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-10
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Clinacanthus nutans is used as traditional medicine in Asia but there are limited scientific studies to support its use.
In this study, the stem and leaf of C.
nutans were extracted using solvents of differing polarities, and their antioxidant capacities were determined using multiple antioxidant assays.
The water and aqueous methanolic leaf extracts were further fractionated and their antioxidant capacities and phenolic compositions were tested.
Furthermore, the efficacies of the water and aqueous methanolic leaf extracts were tested against hyperlipidemia-induced oxidative stress in rats.
Serum and hepatic antioxidant and oxidative stress markers were tested after feeding the rats with high fat diet together with the extracts or simvastatin for 7 weeks.
The results indicated that both leaf extracts attenuated oxidative stress through increasing serum antioxidant enzymes activity and upregulating the expression of hepatic antioxidant genes.
Multiple phenolic compounds were detected in the extracts and fractions of C.
nutans, although protocatechuic acid was one of the most abundant and may have contributed significantly towards the bioactivities of the extracts.
However, synergistic effects of different phenolics may have contributed to the overall bioactivities.
C.
nutans can be a good source of functional ingredients for the management of oxidative stress-related diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sarega, Nadarajan& Imam, Mustapha Umar& Ooi, Der-Jiun& Chan, Kim Wei& Norhaizan, Mohd Esa& Zawawi, Norhasnida…[et al.]. 2016. Phenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113902
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sarega, Nadarajan…[et al.]. Phenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113902
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sarega, Nadarajan& Imam, Mustapha Umar& Ooi, Der-Jiun& Chan, Kim Wei& Norhaizan, Mohd Esa& Zawawi, Norhasnida…[et al.]. Phenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113902
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113902
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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