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Phenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats
Joint Authors
Imam, Mustapha Umar
Ismail, Maznah
Ooi, Der-Jiun
Sarega, Nadarajan
Norhaizan, Mohd Esa
Chan, Kim Wei
Zawawi, Norhasnida
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Clinacanthus nutans is used as traditional medicine in Asia but there are limited scientific studies to support its use.
In this study, the stem and leaf of C.
nutans were extracted using solvents of differing polarities, and their antioxidant capacities were determined using multiple antioxidant assays.
The water and aqueous methanolic leaf extracts were further fractionated and their antioxidant capacities and phenolic compositions were tested.
Furthermore, the efficacies of the water and aqueous methanolic leaf extracts were tested against hyperlipidemia-induced oxidative stress in rats.
Serum and hepatic antioxidant and oxidative stress markers were tested after feeding the rats with high fat diet together with the extracts or simvastatin for 7 weeks.
The results indicated that both leaf extracts attenuated oxidative stress through increasing serum antioxidant enzymes activity and upregulating the expression of hepatic antioxidant genes.
Multiple phenolic compounds were detected in the extracts and fractions of C.
nutans, although protocatechuic acid was one of the most abundant and may have contributed significantly towards the bioactivities of the extracts.
However, synergistic effects of different phenolics may have contributed to the overall bioactivities.
C.
nutans can be a good source of functional ingredients for the management of oxidative stress-related diseases.
American Psychological Association (APA)
Sarega, Nadarajan& Imam, Mustapha Umar& Ooi, Der-Jiun& Chan, Kim Wei& Norhaizan, Mohd Esa& Zawawi, Norhasnida…[et al.]. 2016. Phenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113902
Modern Language Association (MLA)
Sarega, Nadarajan…[et al.]. Phenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113902
American Medical Association (AMA)
Sarega, Nadarajan& Imam, Mustapha Umar& Ooi, Der-Jiun& Chan, Kim Wei& Norhaizan, Mohd Esa& Zawawi, Norhasnida…[et al.]. Phenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113902