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The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System
المؤلفون المشاركون
Villela e Silva, Patrícia
Kiguti, Luiz Ricardo Almeida
Pupo, André Sampaio
Anselmo-Franci, Janete Aparecida
Missassi, Gabriela
De Grava Kempinas, Wilma
dos Santos Borges, Cibele
Barbosa Junior, Fernando
Frenedoso da Silva, Raquel
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Arsenic trioxide (As2O3) has shown effectiveness in treatment of leukemia but is also associated with reproductive toxicity.
Since remediation with N-acetylcysteine (NAC) may mitigate the adverse effects caused by exposure, we assessed the effects of As2O3 and its potential reversibility after exposure cessation or coadministration of NAC.
Animals received 0.3 or 3.0 mg/Kg/day of As2O3 subcutaneously and 40 mM of NAC in tap water.
As2O3 treatment impaired spermatogenesis and sperm motility and decreased seminal vesicle weight and testosterone serum levels; after suspension of treatment, these parameters remained altered.
When NAC was administered, animals showed improvement in sperm parameters and seminal vesicle weight.
In vitro epididymal contractility was increased in As2O3-treated animals.
We concluded that As2O3 is toxic to the male mouse genital system by compromising sperm quality and quantity; these effects persisted even after suspension of the treatment.
However, the coadministration of NAC ameliorates the harmful effects of the drug on the male genital system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Frenedoso da Silva, Raquel& dos Santos Borges, Cibele& Villela e Silva, Patrícia& Missassi, Gabriela& Kiguti, Luiz Ricardo Almeida& Pupo, André Sampaio…[et al.]. 2015. The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113914
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Frenedoso da Silva, Raquel…[et al.]. The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113914
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Frenedoso da Silva, Raquel& dos Santos Borges, Cibele& Villela e Silva, Patrícia& Missassi, Gabriela& Kiguti, Luiz Ricardo Almeida& Pupo, André Sampaio…[et al.]. The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113914
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113914
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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