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The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System
Joint Authors
Villela e Silva, Patrícia
Kiguti, Luiz Ricardo Almeida
Pupo, André Sampaio
Anselmo-Franci, Janete Aparecida
Missassi, Gabriela
De Grava Kempinas, Wilma
dos Santos Borges, Cibele
Barbosa Junior, Fernando
Frenedoso da Silva, Raquel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Arsenic trioxide (As2O3) has shown effectiveness in treatment of leukemia but is also associated with reproductive toxicity.
Since remediation with N-acetylcysteine (NAC) may mitigate the adverse effects caused by exposure, we assessed the effects of As2O3 and its potential reversibility after exposure cessation or coadministration of NAC.
Animals received 0.3 or 3.0 mg/Kg/day of As2O3 subcutaneously and 40 mM of NAC in tap water.
As2O3 treatment impaired spermatogenesis and sperm motility and decreased seminal vesicle weight and testosterone serum levels; after suspension of treatment, these parameters remained altered.
When NAC was administered, animals showed improvement in sperm parameters and seminal vesicle weight.
In vitro epididymal contractility was increased in As2O3-treated animals.
We concluded that As2O3 is toxic to the male mouse genital system by compromising sperm quality and quantity; these effects persisted even after suspension of the treatment.
However, the coadministration of NAC ameliorates the harmful effects of the drug on the male genital system.
American Psychological Association (APA)
Frenedoso da Silva, Raquel& dos Santos Borges, Cibele& Villela e Silva, Patrícia& Missassi, Gabriela& Kiguti, Luiz Ricardo Almeida& Pupo, André Sampaio…[et al.]. 2015. The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113914
Modern Language Association (MLA)
Frenedoso da Silva, Raquel…[et al.]. The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113914
American Medical Association (AMA)
Frenedoso da Silva, Raquel& dos Santos Borges, Cibele& Villela e Silva, Patrícia& Missassi, Gabriela& Kiguti, Luiz Ricardo Almeida& Pupo, André Sampaio…[et al.]. The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113914