Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes
المؤلفون المشاركون
García-Arroyo, Fernando Enrique
Cristóbal-García, Magdalena
Loredo-Mendoza, María Lilia
Sánchez-Lozada, Laura Gabriela
Tostado-González, Montserrat
Tapia, Edilia
Arellano, Abraham
Osorio, Horacio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy.
The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF).
The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephrin expression were assessed.
Diabetic group showed impaired renal function in association with oxidative stress and decreased Nrf2 nuclear translocation.
These results were associated with increased mesangial matrix index, interstitial fibrosis, and increased nephrin expression in cortex and urine excretion.
Additionally, interleukin-1β, IL-6, and transforming growth factor-β1 were increased in plasma and kidney.
MMF treatment conserved renal function, prevented renal structural alterations, and partially prevented the proinflammatory and profibrotic cytokines overexpression.
Despite that MMF treatment induced nephrin overexpression in renal tissue, preventing its urinary loss.
MMF salutary effects were associated with a partial prevention of oxidative stress, increased Nrf2 nuclear translocation, and conservation of antioxidant enzymes in renal tissue.
In conclusion, our results confirm that inflammation is a key factor in the progression of diabetic nephropathy and suggest that treatment with MMF protects the kidney by an antioxidant mechanism, possibly regulated at least in part by the Nrf2/Keap1 system, in addition to its well-known anti-inflammatory effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arellano, Abraham& Tostado-González, Montserrat& García-Arroyo, Fernando Enrique& Cristóbal-García, Magdalena& Loredo-Mendoza, María Lilia& Tapia, Edilia…[et al.]. 2016. Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113946
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arellano, Abraham…[et al.]. Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113946
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arellano, Abraham& Tostado-González, Montserrat& García-Arroyo, Fernando Enrique& Cristóbal-García, Magdalena& Loredo-Mendoza, María Lilia& Tapia, Edilia…[et al.]. Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113946
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113946
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر