Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes
Joint Authors
García-Arroyo, Fernando Enrique
Cristóbal-García, Magdalena
Loredo-Mendoza, María Lilia
Sánchez-Lozada, Laura Gabriela
Tostado-González, Montserrat
Tapia, Edilia
Arellano, Abraham
Osorio, Horacio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy.
The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF).
The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephrin expression were assessed.
Diabetic group showed impaired renal function in association with oxidative stress and decreased Nrf2 nuclear translocation.
These results were associated with increased mesangial matrix index, interstitial fibrosis, and increased nephrin expression in cortex and urine excretion.
Additionally, interleukin-1β, IL-6, and transforming growth factor-β1 were increased in plasma and kidney.
MMF treatment conserved renal function, prevented renal structural alterations, and partially prevented the proinflammatory and profibrotic cytokines overexpression.
Despite that MMF treatment induced nephrin overexpression in renal tissue, preventing its urinary loss.
MMF salutary effects were associated with a partial prevention of oxidative stress, increased Nrf2 nuclear translocation, and conservation of antioxidant enzymes in renal tissue.
In conclusion, our results confirm that inflammation is a key factor in the progression of diabetic nephropathy and suggest that treatment with MMF protects the kidney by an antioxidant mechanism, possibly regulated at least in part by the Nrf2/Keap1 system, in addition to its well-known anti-inflammatory effects.
American Psychological Association (APA)
Arellano, Abraham& Tostado-González, Montserrat& García-Arroyo, Fernando Enrique& Cristóbal-García, Magdalena& Loredo-Mendoza, María Lilia& Tapia, Edilia…[et al.]. 2016. Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113946
Modern Language Association (MLA)
Arellano, Abraham…[et al.]. Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113946
American Medical Association (AMA)
Arellano, Abraham& Tostado-González, Montserrat& García-Arroyo, Fernando Enrique& Cristóbal-García, Magdalena& Loredo-Mendoza, María Lilia& Tapia, Edilia…[et al.]. Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113946