Memory Deficit Recovery after Chronic Vanadium Exposure in Mice

المؤلفون المشاركون

Olopade, James Olukayode
Folarin, Oluwabusayo
Olopade, Funmilayo
Onwuka, Silas

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-01-19

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system.

This work was designed to assess memory deficits in mice chronically exposed to vanadium.

A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into three major groups of vanadium treated, matched controls, and animals exposed to vanadium for three months and thereafter vanadium was withdrawn.

Animals were tested using Morris water maze and forelimb grip test at 3, 6, 9, and 12 months of age.

The results showed that animals across the groups showed no difference in learning but had significant loss in memory abilities after 3 months of vanadium exposure and this trend continued in all vanadium-exposed groups relative to the controls.

Animals exposed to vanadium for three months recovered significantly only 9 months after vanadium withdrawal.

There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and the controls in all age groups.

In conclusion, we have shown that chronic administration of vanadium in mice leads to memory deficit which is reversible but only after a long period of vanadium withdrawal.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Folarin, Oluwabusayo& Olopade, Funmilayo& Onwuka, Silas& Olopade, James Olukayode. 2016. Memory Deficit Recovery after Chronic Vanadium Exposure in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113969

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Folarin, Oluwabusayo…[et al.]. Memory Deficit Recovery after Chronic Vanadium Exposure in Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113969

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Folarin, Oluwabusayo& Olopade, Funmilayo& Onwuka, Silas& Olopade, James Olukayode. Memory Deficit Recovery after Chronic Vanadium Exposure in Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113969

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1113969