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Memory Deficit Recovery after Chronic Vanadium Exposure in Mice
Joint Authors
Olopade, James Olukayode
Folarin, Oluwabusayo
Olopade, Funmilayo
Onwuka, Silas
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system.
This work was designed to assess memory deficits in mice chronically exposed to vanadium.
A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into three major groups of vanadium treated, matched controls, and animals exposed to vanadium for three months and thereafter vanadium was withdrawn.
Animals were tested using Morris water maze and forelimb grip test at 3, 6, 9, and 12 months of age.
The results showed that animals across the groups showed no difference in learning but had significant loss in memory abilities after 3 months of vanadium exposure and this trend continued in all vanadium-exposed groups relative to the controls.
Animals exposed to vanadium for three months recovered significantly only 9 months after vanadium withdrawal.
There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and the controls in all age groups.
In conclusion, we have shown that chronic administration of vanadium in mice leads to memory deficit which is reversible but only after a long period of vanadium withdrawal.
American Psychological Association (APA)
Folarin, Oluwabusayo& Olopade, Funmilayo& Onwuka, Silas& Olopade, James Olukayode. 2016. Memory Deficit Recovery after Chronic Vanadium Exposure in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113969
Modern Language Association (MLA)
Folarin, Oluwabusayo…[et al.]. Memory Deficit Recovery after Chronic Vanadium Exposure in Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113969
American Medical Association (AMA)
Folarin, Oluwabusayo& Olopade, Funmilayo& Onwuka, Silas& Olopade, James Olukayode. Memory Deficit Recovery after Chronic Vanadium Exposure in Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113969