Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice

الملخص EN

The purpose of this study was to evaluate the hepatoprotective effect of an antioxidative nanoparticle ( R N P N ) recently developed against APAP-induced hepatotoxicity in mice.

The effects of oral administration of R N P N to APAP-treated mice were assessed for various biochemical liver function parameters: alanine transaminase (ALT) activity, aspartate transaminase (AST) activity, alkaline phosphatase (ALP) activity, prothrombin time, and serum albumin (ALB) level.

The treatment effects were assessed in terms of free radical parameters: malondialdehyde (MDA) accumulation, glutathione peroxidase (GPx) activity, % inhibition of superoxide anion ( O 2 - ∙ ), and histopathological examination.

The N-acetylcysteine (NAC)-treated group exhibited an enhanced prothrombin time relative to the control group, while R N P N did not prolong prothrombin time.

The R N P N -treated animals exhibited lower levels of ALT, AST, and ALP, while increased ALB levels were measured in these animals compared to those in the other groups.

The R N P N -treated animals furthermore exhibited improved MDA levels, GPx activity, and % inhibition of O 2 - ∙ , which relate to oxidative damage.

Histological staining of liver tissues from R N P N -treated animals did not reveal any microscopic changes relative to the other groups.

The findings of this study suggest that R N P N possesses effective hepatoprotective properties and does not exhibit the notable adverse effects associated with NAC treatment.