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Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice
Joint Authors
Boonruamkaew, Phetcharat
Chonpathompikunlert, Pennapa
Nagasaki, Yukio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The purpose of this study was to evaluate the hepatoprotective effect of an antioxidative nanoparticle ( R N P N ) recently developed against APAP-induced hepatotoxicity in mice.
The effects of oral administration of R N P N to APAP-treated mice were assessed for various biochemical liver function parameters: alanine transaminase (ALT) activity, aspartate transaminase (AST) activity, alkaline phosphatase (ALP) activity, prothrombin time, and serum albumin (ALB) level.
The treatment effects were assessed in terms of free radical parameters: malondialdehyde (MDA) accumulation, glutathione peroxidase (GPx) activity, % inhibition of superoxide anion ( O 2 - ∙ ), and histopathological examination.
The N-acetylcysteine (NAC)-treated group exhibited an enhanced prothrombin time relative to the control group, while R N P N did not prolong prothrombin time.
The R N P N -treated animals exhibited lower levels of ALT, AST, and ALP, while increased ALB levels were measured in these animals compared to those in the other groups.
The R N P N -treated animals furthermore exhibited improved MDA levels, GPx activity, and % inhibition of O 2 - ∙ , which relate to oxidative damage.
Histological staining of liver tissues from R N P N -treated animals did not reveal any microscopic changes relative to the other groups.
The findings of this study suggest that R N P N possesses effective hepatoprotective properties and does not exhibit the notable adverse effects associated with NAC treatment.
American Psychological Association (APA)
Boonruamkaew, Phetcharat& Chonpathompikunlert, Pennapa& Nagasaki, Yukio. 2016. Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113976
Modern Language Association (MLA)
Boonruamkaew, Phetcharat…[et al.]. Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113976
American Medical Association (AMA)
Boonruamkaew, Phetcharat& Chonpathompikunlert, Pennapa& Nagasaki, Yukio. Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113976