PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease
المؤلفون المشاركون
Kuchta, Agnieszka
Strzelecki, Adrian
Ćwiklińska, Agnieszka
Totoń, Magdalena
Gruchała, Marcin
Zdrojewski, Zbigniew
Kortas-Stempak, Barbara
Gliwińska, Anna
Dąbkowski, Kamil
Jankowski, Maciej
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of the study was to estimate association of the extent of angiographically proven coronary artery disease (CAD) with plasma 8-isoprostane F2 (8-iso-PGF2α) levels as a reliable marker of lipid peroxidation and serum activity of paraoxonase-1, which demonstrates the ability to protect against lipid oxidation.
The study included 105 patients with angiographically documented CAD (CAD+) and 45 patients with negative results of coronary angiography (CAD−).
Compared to the control group CAD+ patients were characterized by increased 8-iso-PGF2α levels ( P = 0.007 ) and reduced activity of PON-1 towards paraoxon (PONase, P = 0.002 ) and phenyl acetate (AREase, P = 0.037 ).
Univariate correlation analysis indicated that 8-iso-PGF2α concentrations were positively associated with the severity of CAD as evaluated by the Gensini score ( R = 0.41 , P < 0.001 ) while PONase activity ( R = − 0.26 , P < 0.05 ) and AREase activity ( R = − 0.23 , P < 0.05 ) were inversely correlated with CAD severity.
PONase activity and 8-iso-PGF2α concentration remained independent determinant of atherosclerosis severity in multiple linear regression after adjusting for age, gender, smoking habits, hypertension, type 2 diabetes, statin therapy, and HDL-C and TAG concentration ( β coefficients −0.267; P < 0.05 and 0.368; P < 0.001 , resp.).
The results suggest that PON-1 activity and 8-iso-PGF2α concentration are associated with the presence and extent of coronary stenosis and may be considered additional markers of coronary artery disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuchta, Agnieszka& Strzelecki, Adrian& Ćwiklińska, Agnieszka& Totoń, Magdalena& Gruchała, Marcin& Zdrojewski, Zbigniew…[et al.]. 2015. PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuchta, Agnieszka…[et al.]. PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuchta, Agnieszka& Strzelecki, Adrian& Ćwiklińska, Agnieszka& Totoń, Magdalena& Gruchała, Marcin& Zdrojewski, Zbigniew…[et al.]. PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113985
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر