PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease
Joint Authors
Kuchta, Agnieszka
Strzelecki, Adrian
Ćwiklińska, Agnieszka
Totoń, Magdalena
Gruchała, Marcin
Zdrojewski, Zbigniew
Kortas-Stempak, Barbara
Gliwińska, Anna
Dąbkowski, Kamil
Jankowski, Maciej
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of the study was to estimate association of the extent of angiographically proven coronary artery disease (CAD) with plasma 8-isoprostane F2 (8-iso-PGF2α) levels as a reliable marker of lipid peroxidation and serum activity of paraoxonase-1, which demonstrates the ability to protect against lipid oxidation.
The study included 105 patients with angiographically documented CAD (CAD+) and 45 patients with negative results of coronary angiography (CAD−).
Compared to the control group CAD+ patients were characterized by increased 8-iso-PGF2α levels ( P = 0.007 ) and reduced activity of PON-1 towards paraoxon (PONase, P = 0.002 ) and phenyl acetate (AREase, P = 0.037 ).
Univariate correlation analysis indicated that 8-iso-PGF2α concentrations were positively associated with the severity of CAD as evaluated by the Gensini score ( R = 0.41 , P < 0.001 ) while PONase activity ( R = − 0.26 , P < 0.05 ) and AREase activity ( R = − 0.23 , P < 0.05 ) were inversely correlated with CAD severity.
PONase activity and 8-iso-PGF2α concentration remained independent determinant of atherosclerosis severity in multiple linear regression after adjusting for age, gender, smoking habits, hypertension, type 2 diabetes, statin therapy, and HDL-C and TAG concentration ( β coefficients −0.267; P < 0.05 and 0.368; P < 0.001 , resp.).
The results suggest that PON-1 activity and 8-iso-PGF2α concentration are associated with the presence and extent of coronary stenosis and may be considered additional markers of coronary artery disease.
American Psychological Association (APA)
Kuchta, Agnieszka& Strzelecki, Adrian& Ćwiklińska, Agnieszka& Totoń, Magdalena& Gruchała, Marcin& Zdrojewski, Zbigniew…[et al.]. 2015. PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113985
Modern Language Association (MLA)
Kuchta, Agnieszka…[et al.]. PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113985
American Medical Association (AMA)
Kuchta, Agnieszka& Strzelecki, Adrian& Ćwiklińska, Agnieszka& Totoń, Magdalena& Gruchała, Marcin& Zdrojewski, Zbigniew…[et al.]. PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113985