The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus
المؤلفون المشاركون
Cardona-Muñoz, Ernesto German
Miranda-Díaz, Alejandra Guillermina
Carrillo-Ibarra, Sandra
Cerrillos-Gutiérrez, José Ignacio
Escalante-Núñez, Ariadna
Rojas-Campos, Enrique
Gómez-Navarro, Benjamín
Sifuentes-Franco, Sonia
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To determine the oxidative stress/inflammation behavior in patients with/without acute graft dysfunction (AGD) with Tacrolimus.
Methods.
Cross-sectional study, in renal transplant (RT) recipients (1-yr follow-up).
Patients with AGD and without AGD were included.
Serum IL-6, TNF-α, 8-isoprostanes (8-IP), and Nitric Oxide (NO) were determined by ELISA; C-reactive protein (CRP) was determined by nephelometry; lipid peroxidation products (LPO) and superoxide dismutase (SOD) were determined by colorimetry.
Results.
The AGD presentation was at 5.09 ± 3.07 versus 8.27 ± 3.78 months (p<0.001); CRP >3.19 mg/L was found in 21 versus 19 in the N-AGD group (p=0.83); TNF-α 145.53 ± 18.87 pg/mL versus 125.54 ± 15.92 pg/mL in N-AGD (p=0.64); IL-6 2110.69 ± 350.97 pg/mL versus 1933.42 ± 235.38 pg/mL in N-AGD (p=0.13).
The LPO were higher in AGD (p=0.014): 4.10 ± 0.69 µM versus 2.41 ± 0.29 µM; also levels of 8-IP were higher in AGD 27.47 ± 9.28 pg/mL versus 8.64 ± 1.54 pg/mL (p=0.01).
Serum levels of NO in AGD were lower 138.44 ± 19.20 µmol/L versus 190.57 ± 22.04 µmol/L in N-AGD (p=0.042); antioxidant enzyme SOD activity was significantly diminished in AGD with 9.75 ± 0.52 U/mL versus 11.69 ± 0.55 U/mL in N-AGD (p=0.012).
Discussion.
Patients with RT present with a similar state of the proinflammatory cytokines whether or not they have AGD.
The patients with AGD showed deregulation of the oxidative state with increased LPO and 8-IP and decreased NO and SOD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carrillo-Ibarra, Sandra& Cerrillos-Gutiérrez, José Ignacio& Escalante-Núñez, Ariadna& Rojas-Campos, Enrique& Gómez-Navarro, Benjamín& Sifuentes-Franco, Sonia…[et al.]. 2016. The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114020
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carrillo-Ibarra, Sandra…[et al.]. The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114020
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carrillo-Ibarra, Sandra& Cerrillos-Gutiérrez, José Ignacio& Escalante-Núñez, Ariadna& Rojas-Campos, Enrique& Gómez-Navarro, Benjamín& Sifuentes-Franco, Sonia…[et al.]. The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114020
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114020
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر