The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus
Joint Authors
Cardona-Muñoz, Ernesto German
Miranda-Díaz, Alejandra Guillermina
Carrillo-Ibarra, Sandra
Cerrillos-Gutiérrez, José Ignacio
Escalante-Núñez, Ariadna
Rojas-Campos, Enrique
Gómez-Navarro, Benjamín
Sifuentes-Franco, Sonia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To determine the oxidative stress/inflammation behavior in patients with/without acute graft dysfunction (AGD) with Tacrolimus.
Methods.
Cross-sectional study, in renal transplant (RT) recipients (1-yr follow-up).
Patients with AGD and without AGD were included.
Serum IL-6, TNF-α, 8-isoprostanes (8-IP), and Nitric Oxide (NO) were determined by ELISA; C-reactive protein (CRP) was determined by nephelometry; lipid peroxidation products (LPO) and superoxide dismutase (SOD) were determined by colorimetry.
Results.
The AGD presentation was at 5.09 ± 3.07 versus 8.27 ± 3.78 months (p<0.001); CRP >3.19 mg/L was found in 21 versus 19 in the N-AGD group (p=0.83); TNF-α 145.53 ± 18.87 pg/mL versus 125.54 ± 15.92 pg/mL in N-AGD (p=0.64); IL-6 2110.69 ± 350.97 pg/mL versus 1933.42 ± 235.38 pg/mL in N-AGD (p=0.13).
The LPO were higher in AGD (p=0.014): 4.10 ± 0.69 µM versus 2.41 ± 0.29 µM; also levels of 8-IP were higher in AGD 27.47 ± 9.28 pg/mL versus 8.64 ± 1.54 pg/mL (p=0.01).
Serum levels of NO in AGD were lower 138.44 ± 19.20 µmol/L versus 190.57 ± 22.04 µmol/L in N-AGD (p=0.042); antioxidant enzyme SOD activity was significantly diminished in AGD with 9.75 ± 0.52 U/mL versus 11.69 ± 0.55 U/mL in N-AGD (p=0.012).
Discussion.
Patients with RT present with a similar state of the proinflammatory cytokines whether or not they have AGD.
The patients with AGD showed deregulation of the oxidative state with increased LPO and 8-IP and decreased NO and SOD.
American Psychological Association (APA)
Carrillo-Ibarra, Sandra& Cerrillos-Gutiérrez, José Ignacio& Escalante-Núñez, Ariadna& Rojas-Campos, Enrique& Gómez-Navarro, Benjamín& Sifuentes-Franco, Sonia…[et al.]. 2016. The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114020
Modern Language Association (MLA)
Carrillo-Ibarra, Sandra…[et al.]. The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114020
American Medical Association (AMA)
Carrillo-Ibarra, Sandra& Cerrillos-Gutiérrez, José Ignacio& Escalante-Núñez, Ariadna& Rojas-Campos, Enrique& Gómez-Navarro, Benjamín& Sifuentes-Franco, Sonia…[et al.]. The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114020