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Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2STAT3 Signaling
المؤلفون المشاركون
Han, Shichao
Cai, Weixia
Yang, Xuekang
Jia, Yanhui
Zheng, Zhao
Wang, Hongtao
Gao, Jianxin
Hu, Dahai
Yang, Tao
Guan, Hao
Zhu, Xiongxiang
Guo, Haitao
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-05
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Oxidative stress plays an important role in burn-induced myocardial injury, but the cellular mechanisms that control reactive oxygen species (ROS) production and scavenging are not fully understood.
This study demonstrated that blockade of Notch signaling via knockout of the transcription factor RBP-J or a pharmacological inhibitor aggravated postburn myocardial injury, which manifested as deteriorated serum CK, CK-MB, and LDH levels and increased apoptosis in vitro and in vivo.
Interruption of Notch signaling increased intracellular ROS production, and a ROS scavenger reversed the exacerbated myocardial injury after Notch signaling blockade.
These results suggest that Notch signaling deficiency aggravated postburn myocardial injury through increased ROS levels.
Notch signaling blockade also decreased MnSOD expression in vitro and in vivo.
Notably, Notch signaling blockade downregulated p-JAK2 and p-STAT3 expression.
Inhibition of JAK2/STAT3 signaling with AG490 markedly decreased MnSOD expression, increased ROS production, and aggravated myocardial injury.
AG490 plus GSI exerted no additional effects.
These results demonstrate that Notch signaling protects against burn-induced myocardial injury through JAK2/STAT3 signaling, which activates the expression of MnSOD and leads to decreased ROS levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Weixia& Yang, Xuekang& Han, Shichao& Guo, Haitao& Zheng, Zhao& Wang, Hongtao…[et al.]. 2016. Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2STAT3 Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114032
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Weixia…[et al.]. Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2STAT3 Signaling. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114032
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Weixia& Yang, Xuekang& Han, Shichao& Guo, Haitao& Zheng, Zhao& Wang, Hongtao…[et al.]. Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2STAT3 Signaling. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114032
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114032
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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