Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats
المؤلفون المشاركون
Antonio Behr, Guilherme
Gelain, Daniel Pens
Gasparotto, Juciano
Morrone, Maurilio da Silva
Schnorr, Carlos Eduardo
Bortolin, Rafael Calixto
da Boit Martinello, Katia
Saldanha Henkin, Bernardo
Rabello, Thallita Kelly
Zanotto-Filho, Alfeu
Fonseca Moreira, José Cláudio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate the potential of curcumin oral supplementation (50 and 100 mg/Kg/day, for 30 days) in circumventing menopause-associated oxidative stress and lipid profile dysfunctions in a rat ovariectomy (OVX) model.
Female Wistar rats were operated and randomly divided into either sham-operated or OVX groups.
Sham-operated group ( n = 8 ) and one OVX group ( n = 11 ) were treated with vehicle (refined olive oil), and the other two OVX groups received curcumin at 50 or 100 mg/Kg/day doses ( n = 8 /group).
OVX vehicle-treated animals presented a higher deposition of intestinal adipose tissue as well as increased serum levels of IL-6, LDL, and total cholesterol when compared to sham-operated rats.
In addition, several oxidative stress markers in serum, blood, and liver (such as TBARS, carbonyl, reduced-sulphydryl, and nonenzymatic antioxidant defenses) were altered toward a prooxidant status by OVX.
Interestingly, curcumin supplementation attenuated most of these parameters to sham comparable values.
Thus, the herein presented results show that curcumin may be useful to ameliorate lipid metabolism alterations and oxidative damage associated with hormone deprivation in menopause.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morrone, Maurilio da Silva& Schnorr, Carlos Eduardo& Antonio Behr, Guilherme& Gasparotto, Juciano& Bortolin, Rafael Calixto& da Boit Martinello, Katia…[et al.]. 2015. Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114040
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morrone, Maurilio da Silva…[et al.]. Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114040
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morrone, Maurilio da Silva& Schnorr, Carlos Eduardo& Antonio Behr, Guilherme& Gasparotto, Juciano& Bortolin, Rafael Calixto& da Boit Martinello, Katia…[et al.]. Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114040
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114040
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر