Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats
Joint Authors
Antonio Behr, Guilherme
Gelain, Daniel Pens
Gasparotto, Juciano
Morrone, Maurilio da Silva
Schnorr, Carlos Eduardo
Bortolin, Rafael Calixto
da Boit Martinello, Katia
Saldanha Henkin, Bernardo
Rabello, Thallita Kelly
Zanotto-Filho, Alfeu
Fonseca Moreira, José Cláudio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to investigate the potential of curcumin oral supplementation (50 and 100 mg/Kg/day, for 30 days) in circumventing menopause-associated oxidative stress and lipid profile dysfunctions in a rat ovariectomy (OVX) model.
Female Wistar rats were operated and randomly divided into either sham-operated or OVX groups.
Sham-operated group ( n = 8 ) and one OVX group ( n = 11 ) were treated with vehicle (refined olive oil), and the other two OVX groups received curcumin at 50 or 100 mg/Kg/day doses ( n = 8 /group).
OVX vehicle-treated animals presented a higher deposition of intestinal adipose tissue as well as increased serum levels of IL-6, LDL, and total cholesterol when compared to sham-operated rats.
In addition, several oxidative stress markers in serum, blood, and liver (such as TBARS, carbonyl, reduced-sulphydryl, and nonenzymatic antioxidant defenses) were altered toward a prooxidant status by OVX.
Interestingly, curcumin supplementation attenuated most of these parameters to sham comparable values.
Thus, the herein presented results show that curcumin may be useful to ameliorate lipid metabolism alterations and oxidative damage associated with hormone deprivation in menopause.
American Psychological Association (APA)
Morrone, Maurilio da Silva& Schnorr, Carlos Eduardo& Antonio Behr, Guilherme& Gasparotto, Juciano& Bortolin, Rafael Calixto& da Boit Martinello, Katia…[et al.]. 2015. Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114040
Modern Language Association (MLA)
Morrone, Maurilio da Silva…[et al.]. Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114040
American Medical Association (AMA)
Morrone, Maurilio da Silva& Schnorr, Carlos Eduardo& Antonio Behr, Guilherme& Gasparotto, Juciano& Bortolin, Rafael Calixto& da Boit Martinello, Katia…[et al.]. Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114040