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Identification of Redox and Glucose-Dependent Txnip Protein Interactions
المؤلفون المشاركون
Forred, Benjamin J.
Neuharth, Skyla
Kim, Dae In
Amolins, Michael W.
Motamedchaboki, Khatereh
Roux, Kyle J.
Vitiello, Peter F.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Thioredoxin-interacting protein (Txnip) acts as a negative regulator of thioredoxin function and is a critical modulator of several diseases including, but not limited to, diabetes, ischemia-reperfusion cardiac injury, and carcinogenesis.
Therefore, Txnip has become an attractive therapeutic target to alleviate disease pathologies.
Although Txnip has been implicated with numerous cellular processes such as proliferation, fatty acid and glucose metabolism, inflammation, and apoptosis, the molecular mechanisms underlying these processes are largely unknown.
The objective of these studies was to identify Txnip interacting proteins using the proximity-based labeling method, BioID, to understand differential regulation of pleiotropic Txnip cellular functions.
The BioID transgene fused to Txnip expressed in HEK293 identified 31 interacting proteins.
Many protein interactions were redox-dependent and were disrupted through mutation of a previously described reactive cysteine (C247S).
Furthermore, we demonstrate that this model can be used to identify dynamic Txnip interactions due to known physiological regulators such as hyperglycemia.
These data identify novel Txnip protein interactions and demonstrate dynamic interactions dependent on redox and glucose perturbations, providing clarification to the pleiotropic cellular functions of Txnip.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Forred, Benjamin J.& Neuharth, Skyla& Kim, Dae In& Amolins, Michael W.& Motamedchaboki, Khatereh& Roux, Kyle J.…[et al.]. 2016. Identification of Redox and Glucose-Dependent Txnip Protein Interactions. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114055
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Forred, Benjamin J.…[et al.]. Identification of Redox and Glucose-Dependent Txnip Protein Interactions. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114055
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Forred, Benjamin J.& Neuharth, Skyla& Kim, Dae In& Amolins, Michael W.& Motamedchaboki, Khatereh& Roux, Kyle J.…[et al.]. Identification of Redox and Glucose-Dependent Txnip Protein Interactions. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114055
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114055
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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