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Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration
المؤلفون المشاركون
Dvořák, Aleš
Alán, Lukáš
Vítek, Libor
Zelenka, Jaroslav
Zadinová, Marie
Haluzík, Martin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Mild constitutive hyperbilirubinemia is associated with a reduced risk of cardiovascular diseases, diabetes, and cancer.
Since these pathologies are associated with aging, inflammation, and oxidative stress, we investigated whether hyperbilirubinemia interferes with ROS homeostasis in cell cultures and with inflammation, senescence, and mitochondrial dysfunction in aged rats.
Human embryonic kidney cells and rat primary fibroblasts showed a dose-dependent decrease in the ratio of oxidized/reduced glutathione, intracellular H2O2 levels, and mitochondrial ROS production, with increasing bilirubin concentrations in the culture media.
Compared to their normobilirubinemic siblings, aged hyperbilirubinemic Gunn rats showed significantly smaller amounts of visceral fat, better glucose tolerance, and decreased serum levels of proinflammatory cytokines TNFα, IL-1β, and IL-18.
Simultaneously, livers from Gunn rats showed decreased expression of senescence markers and cell cycle inhibitors p21 and p16.
Mitochondria from aged Gunn rats showed higher respiration and lower H2O2 production compared to controls.
In conclusion, we demonstrated that mildly elevated serum bilirubin is generally associated with attenuation of oxidative stress and with better anthropometric parameters, decreased inflammatory status, increased glucose tolerance, fewer signs of cellular senescence, and enhanced mitochondrial function in aged rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zelenka, Jaroslav& Dvořák, Aleš& Alán, Lukáš& Zadinová, Marie& Haluzík, Martin& Vítek, Libor. 2016. Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114090
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zelenka, Jaroslav…[et al.]. Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114090
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zelenka, Jaroslav& Dvořák, Aleš& Alán, Lukáš& Zadinová, Marie& Haluzík, Martin& Vítek, Libor. Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114090
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114090
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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