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Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration
Joint Authors
Dvořák, Aleš
Alán, Lukáš
Vítek, Libor
Zelenka, Jaroslav
Zadinová, Marie
Haluzík, Martin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mild constitutive hyperbilirubinemia is associated with a reduced risk of cardiovascular diseases, diabetes, and cancer.
Since these pathologies are associated with aging, inflammation, and oxidative stress, we investigated whether hyperbilirubinemia interferes with ROS homeostasis in cell cultures and with inflammation, senescence, and mitochondrial dysfunction in aged rats.
Human embryonic kidney cells and rat primary fibroblasts showed a dose-dependent decrease in the ratio of oxidized/reduced glutathione, intracellular H2O2 levels, and mitochondrial ROS production, with increasing bilirubin concentrations in the culture media.
Compared to their normobilirubinemic siblings, aged hyperbilirubinemic Gunn rats showed significantly smaller amounts of visceral fat, better glucose tolerance, and decreased serum levels of proinflammatory cytokines TNFα, IL-1β, and IL-18.
Simultaneously, livers from Gunn rats showed decreased expression of senescence markers and cell cycle inhibitors p21 and p16.
Mitochondria from aged Gunn rats showed higher respiration and lower H2O2 production compared to controls.
In conclusion, we demonstrated that mildly elevated serum bilirubin is generally associated with attenuation of oxidative stress and with better anthropometric parameters, decreased inflammatory status, increased glucose tolerance, fewer signs of cellular senescence, and enhanced mitochondrial function in aged rats.
American Psychological Association (APA)
Zelenka, Jaroslav& Dvořák, Aleš& Alán, Lukáš& Zadinová, Marie& Haluzík, Martin& Vítek, Libor. 2016. Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114090
Modern Language Association (MLA)
Zelenka, Jaroslav…[et al.]. Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114090
American Medical Association (AMA)
Zelenka, Jaroslav& Dvořák, Aleš& Alán, Lukáš& Zadinová, Marie& Haluzík, Martin& Vítek, Libor. Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114090