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Induction Effect of Bisphenol A on Gene Expression Involving Hepatic Oxidative Stress in Rat
المؤلفون المشاركون
Kazemi, Sohrab
Mousavi, Seydeh Narges
Aghapour, Fahimeh
Rezaee, Boshra
Sadeghi, Farzin
Moghadamnia, Ali Akbar
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-10
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background and Objective.
Bisphenol A (BPA) is an abundantly used xenoestrogenic chemical which may cause various disorders in body.
In the present study, we sought to investigate the effects of various doses of BPA on hepatic oxidative stress-related gene expression in rats.
Methods.
Male Wistar rats weighing 150–200 g were used in this study.
Three doses of the BPA (5, 25, and 125 μg/kg) in corn oil were administered as gavage during 35 consecutive days.
After the experiment, the rats were expired and the livers were removed and stored at −80°C freezer for RNA extraction.
Findings.
The Real Time PCR showed increased expression of HO-1 in the rats receiving BPA doses compared to the control group.
This effect was dose-dependent and higher at doses of 25 and 125 μg/kg than 5 μg/kg of body weight (p<0.05).
It was also demonstrated that various doses BPA can increase GADD45B gene expression compared to control group.
That expression was significantly dominant in the lowest dose (5 μg/kg) of the BPA (p<0.05).
The final body weights (168.0±10.0 gr) in the treatment group [BPA (125 μg/kg)] showed a significant decrease compared to control group (191.60±6.50 gr).
Conclusion.
These findings demonstrate that BPA generated ROS and increased the antioxidant gene expression that causes hepatotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kazemi, Sohrab& Mousavi, Seydeh Narges& Aghapour, Fahimeh& Rezaee, Boshra& Sadeghi, Farzin& Moghadamnia, Ali Akbar. 2016. Induction Effect of Bisphenol A on Gene Expression Involving Hepatic Oxidative Stress in Rat. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1114099
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kazemi, Sohrab…[et al.]. Induction Effect of Bisphenol A on Gene Expression Involving Hepatic Oxidative Stress in Rat. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1114099
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kazemi, Sohrab& Mousavi, Seydeh Narges& Aghapour, Fahimeh& Rezaee, Boshra& Sadeghi, Farzin& Moghadamnia, Ali Akbar. Induction Effect of Bisphenol A on Gene Expression Involving Hepatic Oxidative Stress in Rat. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1114099
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114099
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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