![](/images/graphics-bg.png)
Vascular Protective Effect of an Ethanol Extract of Camellia japonica Fruit: Endothelium-Dependent Relaxation of Coronary Artery and Reduction of Smooth Muscle Cell Migration
المؤلفون المشاركون
Kim, Dong-Wook
Lee, Hyun-Ho
Wi, An-Jin
Park, Whoa-Shig
Oak, Min-Ho
Park, Sin-Hee
Shim, Bong-Sup
Yoon, Jun-Seong
Lee, Hye-Won
Yoo, Seok-Bong
Kim, Hyun-Jung
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Camellia japonica is a popular garden plant in Asia and widely used as cosmetic sources and traditional medicine.
However, the possibility that C.
japonica affects cardiovascular system remains unclear.
The aim of the present study was to evaluate vascular effects of an extract of C.
japonica.
Vascular reactivity was assessed in organ baths using porcine coronary arteries and inhibition of proliferation and migration were assessed using human vascular smooth muscle cells (VSMCs).
All four different parts, leaf, stem, flower, and fruits, caused concentration-dependent relaxations and C.
japonica fruit (CJF) extract showed the strongest vasorelaxation and its effect was endothelium dependent.
Relaxations to CJF were markedly reduced by inhibitor of endothelial nitric oxide synthase (eNOS) and inhibitor of PI3-kinase, but not affected by inhibitor of cyclooxygenase and endothelium-derived hyperpolarizing factor-mediated response.
CJF induced activated a time- and concentration-dependent phosphorylation of eNOS in endothelial cells.
Altogether, these studies have demonstrated that CJF is a potent endothelium-dependent vasodilator and this effect was involved in, at least in part, PI3K-eNOS-NO pathway.
Moreover, CJF attenuated TNF-α induced proliferation and PDGF-BB induced migration of VSMCs.
The present findings indicate that CJF could be a valuable candidate of herbal medicine for cardiovascular diseases associated with endothelial dysfunction and atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Sin-Hee& Shim, Bong-Sup& Yoon, Jun-Seong& Lee, Hyun-Ho& Lee, Hye-Won& Yoo, Seok-Bong…[et al.]. 2015. Vascular Protective Effect of an Ethanol Extract of Camellia japonica Fruit: Endothelium-Dependent Relaxation of Coronary Artery and Reduction of Smooth Muscle Cell Migration. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114104
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Sin-Hee…[et al.]. Vascular Protective Effect of an Ethanol Extract of Camellia japonica Fruit: Endothelium-Dependent Relaxation of Coronary Artery and Reduction of Smooth Muscle Cell Migration. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114104
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Sin-Hee& Shim, Bong-Sup& Yoon, Jun-Seong& Lee, Hyun-Ho& Lee, Hye-Won& Yoo, Seok-Bong…[et al.]. Vascular Protective Effect of an Ethanol Extract of Camellia japonica Fruit: Endothelium-Dependent Relaxation of Coronary Artery and Reduction of Smooth Muscle Cell Migration. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114104
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114104
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)