Vascular Protective Effect of an Ethanol Extract of Camellia japonica Fruit: Endothelium-Dependent Relaxation of Coronary Artery and Reduction of Smooth Muscle Cell Migration
Joint Authors
Kim, Dong-Wook
Lee, Hyun-Ho
Wi, An-Jin
Park, Whoa-Shig
Oak, Min-Ho
Park, Sin-Hee
Shim, Bong-Sup
Yoon, Jun-Seong
Lee, Hye-Won
Yoo, Seok-Bong
Kim, Hyun-Jung
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Camellia japonica is a popular garden plant in Asia and widely used as cosmetic sources and traditional medicine.
However, the possibility that C.
japonica affects cardiovascular system remains unclear.
The aim of the present study was to evaluate vascular effects of an extract of C.
japonica.
Vascular reactivity was assessed in organ baths using porcine coronary arteries and inhibition of proliferation and migration were assessed using human vascular smooth muscle cells (VSMCs).
All four different parts, leaf, stem, flower, and fruits, caused concentration-dependent relaxations and C.
japonica fruit (CJF) extract showed the strongest vasorelaxation and its effect was endothelium dependent.
Relaxations to CJF were markedly reduced by inhibitor of endothelial nitric oxide synthase (eNOS) and inhibitor of PI3-kinase, but not affected by inhibitor of cyclooxygenase and endothelium-derived hyperpolarizing factor-mediated response.
CJF induced activated a time- and concentration-dependent phosphorylation of eNOS in endothelial cells.
Altogether, these studies have demonstrated that CJF is a potent endothelium-dependent vasodilator and this effect was involved in, at least in part, PI3K-eNOS-NO pathway.
Moreover, CJF attenuated TNF-α induced proliferation and PDGF-BB induced migration of VSMCs.
The present findings indicate that CJF could be a valuable candidate of herbal medicine for cardiovascular diseases associated with endothelial dysfunction and atherosclerosis.
American Psychological Association (APA)
Park, Sin-Hee& Shim, Bong-Sup& Yoon, Jun-Seong& Lee, Hyun-Ho& Lee, Hye-Won& Yoo, Seok-Bong…[et al.]. 2015. Vascular Protective Effect of an Ethanol Extract of Camellia japonica Fruit: Endothelium-Dependent Relaxation of Coronary Artery and Reduction of Smooth Muscle Cell Migration. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114104
Modern Language Association (MLA)
Park, Sin-Hee…[et al.]. Vascular Protective Effect of an Ethanol Extract of Camellia japonica Fruit: Endothelium-Dependent Relaxation of Coronary Artery and Reduction of Smooth Muscle Cell Migration. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114104
American Medical Association (AMA)
Park, Sin-Hee& Shim, Bong-Sup& Yoon, Jun-Seong& Lee, Hyun-Ho& Lee, Hye-Won& Yoo, Seok-Bong…[et al.]. Vascular Protective Effect of an Ethanol Extract of Camellia japonica Fruit: Endothelium-Dependent Relaxation of Coronary Artery and Reduction of Smooth Muscle Cell Migration. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114104