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Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice
المؤلفون المشاركون
Kim, Eun Nim
Kim, Min Young
Yoon, Hye Eun
Jang, In-Ae
Ban, Tae Hyun
Park, Cheol Whee
Choi, Bum Soon
Lim, Ji Hee
Chang, Yoon Sik
Shin, Seok Joon
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-20
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
This study evaluated whether the change in the renin-angiotensin system (RAS) is associated with arterial aging in mice.
Methods.
Histologic changes and expressions of transforming growth factor-β (TGF-β), collagen IV, fibronectin, angiotensin II (Ang II), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), prorenin receptor (PRR), Mas receptor (MasR), endothelial nitric oxide synthase (eNOS), NADPH oxidase 2 and oxidase 4 (Nox2 and Nox4), 8-hydroxy-2′-deoxyguanosine (8-OHdG), 3-nitrotyrosine, and superoxide dismutase 1 and dismutase 2 (SOD1 and SOD2) were measured in the thoracic aortas from 2-month-old, 12-month-old, and 24-month-old C57/BL6 mice.
Results.
Twenty-four-month-old mice showed significantly increased aortic media thickness and expressions of TGF-β, collagen IV, and fibronectin, compared to 2-month-old and 12-month-old mice.
The expressions of PRR, ACE, and Ang II, and AT1R-positive area significantly increased, whereas expressions of ACE2 and MasR and AT2R-positive area decreased with age.
The expressions of phosphorylated serine1177-eNOS, SOD1, and SOD2 decreased, and the 8-OHdG-positive area and the 3-nitrotyrosine-positive area increased with age.
The expression of Nox2 significantly increased with age, but that of Nox4 did not change.
Conclusions.
The enhanced PRR-ACE-Ang II-AT1R axis and reduced ACE2-MasR axis were associated with arterial aging in mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yoon, Hye Eun& Kim, Eun Nim& Kim, Min Young& Lim, Ji Hee& Jang, In-Ae& Ban, Tae Hyun…[et al.]. 2016. Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114131
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yoon, Hye Eun…[et al.]. Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114131
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yoon, Hye Eun& Kim, Eun Nim& Kim, Min Young& Lim, Ji Hee& Jang, In-Ae& Ban, Tae Hyun…[et al.]. Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114131
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114131
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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