Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice
Joint Authors
Kim, Eun Nim
Kim, Min Young
Yoon, Hye Eun
Jang, In-Ae
Ban, Tae Hyun
Park, Cheol Whee
Choi, Bum Soon
Lim, Ji Hee
Chang, Yoon Sik
Shin, Seok Joon
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
This study evaluated whether the change in the renin-angiotensin system (RAS) is associated with arterial aging in mice.
Methods.
Histologic changes and expressions of transforming growth factor-β (TGF-β), collagen IV, fibronectin, angiotensin II (Ang II), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), prorenin receptor (PRR), Mas receptor (MasR), endothelial nitric oxide synthase (eNOS), NADPH oxidase 2 and oxidase 4 (Nox2 and Nox4), 8-hydroxy-2′-deoxyguanosine (8-OHdG), 3-nitrotyrosine, and superoxide dismutase 1 and dismutase 2 (SOD1 and SOD2) were measured in the thoracic aortas from 2-month-old, 12-month-old, and 24-month-old C57/BL6 mice.
Results.
Twenty-four-month-old mice showed significantly increased aortic media thickness and expressions of TGF-β, collagen IV, and fibronectin, compared to 2-month-old and 12-month-old mice.
The expressions of PRR, ACE, and Ang II, and AT1R-positive area significantly increased, whereas expressions of ACE2 and MasR and AT2R-positive area decreased with age.
The expressions of phosphorylated serine1177-eNOS, SOD1, and SOD2 decreased, and the 8-OHdG-positive area and the 3-nitrotyrosine-positive area increased with age.
The expression of Nox2 significantly increased with age, but that of Nox4 did not change.
Conclusions.
The enhanced PRR-ACE-Ang II-AT1R axis and reduced ACE2-MasR axis were associated with arterial aging in mice.
American Psychological Association (APA)
Yoon, Hye Eun& Kim, Eun Nim& Kim, Min Young& Lim, Ji Hee& Jang, In-Ae& Ban, Tae Hyun…[et al.]. 2016. Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114131
Modern Language Association (MLA)
Yoon, Hye Eun…[et al.]. Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114131
American Medical Association (AMA)
Yoon, Hye Eun& Kim, Eun Nim& Kim, Min Young& Lim, Ji Hee& Jang, In-Ae& Ban, Tae Hyun…[et al.]. Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114131