Differential Expression of NADPH Oxidases Depends on Skeletal Muscle Fiber Type in Rats
المؤلفون المشاركون
Loureiro, Adriano César Carneiro
Rêgo-Monteiro, Igor Coutinho do
Louzada, Ruy A.
Ortenzi, Victor Hugo
Aguiar, Angélica Ponte de
Abreu, Ewerton Sousa de
Cavalcanti-de-Albuquerque, João Paulo Albuquerque
Hecht, Fabio
Oliveira, Ariclécio Cunha de
Ceccatto, Vânia Marilande
Fortunato, Rodrigo S.
Carvalho, Denise P.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
NADPH oxidases (NOX) are important sources of reactive oxygen species (ROS) in skeletal muscle, being involved in excitation-contraction coupling.
Thus, we aimed to investigate if NOX activity and expression in skeletal muscle are fiber type specific and the possible contribution of this difference to cellular oxidative stress.
Oxygen consumption rate, NOX activity and mRNA levels, and the activity of catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD), as well as the reactive protein thiol levels, were measured in the soleus (SOL), red gastrocnemius (RG), and white gastrocnemius (WG) muscles of rats.
RG showed higher oxygen consumption flow than SOL and WG, while SOL had higher oxygen consumption than WG.
SOL showed higher NOX activity, as well as NOX2 and NOX4 mRNA levels, antioxidant enzymatic activities, and reactive protein thiol contents when compared to WG and RG.
NOX activity and NOX4 mRNA levels as well as antioxidant enzymatic activities were higher in RG than in WG.
Physical exercise increased NOX activity in SOL and RG, specifically NOX2 mRNA levels in RG and NOX4 mRNA levels in SOL.
In conclusion, we demonstrated that NOX activity and expression differ according to the skeletal muscle fiber type, as well as antioxidant defense.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Loureiro, Adriano César Carneiro& Rêgo-Monteiro, Igor Coutinho do& Louzada, Ruy A.& Ortenzi, Victor Hugo& Aguiar, Angélica Ponte de& Abreu, Ewerton Sousa de…[et al.]. 2016. Differential Expression of NADPH Oxidases Depends on Skeletal Muscle Fiber Type in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114132
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Loureiro, Adriano César Carneiro…[et al.]. Differential Expression of NADPH Oxidases Depends on Skeletal Muscle Fiber Type in Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114132
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Loureiro, Adriano César Carneiro& Rêgo-Monteiro, Igor Coutinho do& Louzada, Ruy A.& Ortenzi, Victor Hugo& Aguiar, Angélica Ponte de& Abreu, Ewerton Sousa de…[et al.]. Differential Expression of NADPH Oxidases Depends on Skeletal Muscle Fiber Type in Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114132
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114132
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر