Ginkgo Biloba Ameliorates Subfertility Induced by Testicular IschemiaReperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism
المؤلفون المشاركون
Ahmed, Asmaa Ibrahim
Lasheen, Noha N.
El-Zawahry, Khaled Mohamed
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-22
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Testicular torsion, a surgical emergency, could affect the endocrine and exocrine testicular functions.
This study demonstrates histopathological and physiological effects of testicular ischemia/perfusion (I/R) injury and the possible protective effects of Ginkgo biloba treatment.
Fifty adult male Wistar rats, 180–200 gm, were randomly divided into sham-operated, Gingko biloba supplemented, ischemia only, I/R, and Gingko biloba treated I/R groups.
Overnight fasted rats were anaesthetized by Pentobarbital; I/R was performed by left testis 720° rotation in I/R and treated I/R groups.
Orchiectomy was performed for histopathological studies and detection of mitochondrial NAD+.
Determination of free testosterone, FSH, TNF-α, and IL1-β in plasma was performed.
Plasma-free testosterone was significantly decreased, while plasma FSH, TNF-α, IL-1β, and testicular mitochondrial NAD+ were significantly increased in I/R group compared to control group.
These parameters were reversed in Gingko biloba treated I/R group compared to I/R group.
I/R caused marked testicular damage and increased APAF-1 in the apoptotic cells which were reversed by Ginkgo biloba treatment.
It could be concluded that I/R caused subfertility induced by apoptosis and oxidative stress manifested by the elevated testicular mitochondrial NAD+, which is considered a new possible mechanism.
Also, testicular injury could be reduced by Gingko biloba administration alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmed, Asmaa Ibrahim& Lasheen, Noha N.& El-Zawahry, Khaled Mohamed. 2016. Ginkgo Biloba Ameliorates Subfertility Induced by Testicular IschemiaReperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114151
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmed, Asmaa Ibrahim…[et al.]. Ginkgo Biloba Ameliorates Subfertility Induced by Testicular IschemiaReperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1114151
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmed, Asmaa Ibrahim& Lasheen, Noha N.& El-Zawahry, Khaled Mohamed. Ginkgo Biloba Ameliorates Subfertility Induced by Testicular IschemiaReperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114151
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114151
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر