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Ginkgo Biloba Ameliorates Subfertility Induced by Testicular IschemiaReperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism
Joint Authors
Ahmed, Asmaa Ibrahim
Lasheen, Noha N.
El-Zawahry, Khaled Mohamed
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Testicular torsion, a surgical emergency, could affect the endocrine and exocrine testicular functions.
This study demonstrates histopathological and physiological effects of testicular ischemia/perfusion (I/R) injury and the possible protective effects of Ginkgo biloba treatment.
Fifty adult male Wistar rats, 180–200 gm, were randomly divided into sham-operated, Gingko biloba supplemented, ischemia only, I/R, and Gingko biloba treated I/R groups.
Overnight fasted rats were anaesthetized by Pentobarbital; I/R was performed by left testis 720° rotation in I/R and treated I/R groups.
Orchiectomy was performed for histopathological studies and detection of mitochondrial NAD+.
Determination of free testosterone, FSH, TNF-α, and IL1-β in plasma was performed.
Plasma-free testosterone was significantly decreased, while plasma FSH, TNF-α, IL-1β, and testicular mitochondrial NAD+ were significantly increased in I/R group compared to control group.
These parameters were reversed in Gingko biloba treated I/R group compared to I/R group.
I/R caused marked testicular damage and increased APAF-1 in the apoptotic cells which were reversed by Ginkgo biloba treatment.
It could be concluded that I/R caused subfertility induced by apoptosis and oxidative stress manifested by the elevated testicular mitochondrial NAD+, which is considered a new possible mechanism.
Also, testicular injury could be reduced by Gingko biloba administration alone.
American Psychological Association (APA)
Ahmed, Asmaa Ibrahim& Lasheen, Noha N.& El-Zawahry, Khaled Mohamed. 2016. Ginkgo Biloba Ameliorates Subfertility Induced by Testicular IschemiaReperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114151
Modern Language Association (MLA)
Ahmed, Asmaa Ibrahim…[et al.]. Ginkgo Biloba Ameliorates Subfertility Induced by Testicular IschemiaReperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1114151
American Medical Association (AMA)
Ahmed, Asmaa Ibrahim& Lasheen, Noha N.& El-Zawahry, Khaled Mohamed. Ginkgo Biloba Ameliorates Subfertility Induced by Testicular IschemiaReperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114151